96859-50-6

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 40207-03-2 p-Anisidinothioformyl-hydrazin 
• 118-92-3 anthranilic acid 
• 1898-06-2 3-amino-2-methyl-4-oxoquinazoline 
• 104-94-9 4-methoxy-aniline 
• 676244-29-4 (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 117054-60-1 1-(4-Methoxy-phenyl)-3-(2-methyl-4-oxo-4H-quinazolin-3-yl)-5-phenylaminomethyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-47-4 1-(4-Methoxy-phenyl)-3-(2-methyl-4-oxo-4H-quinazolin-3-yl)-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-33-8 1-(4-Methoxy-phenyl)-3-(2-methyl-4-oxo-4H-quinazolin-3-yl)-2-thioxo-dihydro-pyrimidine-4,6-dione 

Relevant academic research and scientific papers

Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones

A series of novel 2-methyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by treating (2-methyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The compounds synthesized were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds VA2, VA3 and VA4 shown more potent analgesic activity, and the compounds VA3 and VA4 shown more potent anti-inflammatory activity than the reference compound diclofinac sodium.

Synthesis of some 2-methyl-3-(arylthiocarbamido) quinazol-4-ones and 2-methyl-3-(arylidencarboxamido) quinazol-4-ones as potential antimicrobial agents

Some quinazolone derivatives of 2-methyl-3-(arylthiocarbamido) quinazol-4-ones (2) and 2-methyl-3(arylidencarboxamido) quinazol-4-ones (3) have been synthesized and assayed for their possible antibacterial activity against Bacillus subtilis, Bacillus cereus, Salmonella aureus, Salmonella lutae and antiviral activity against Gomphrena mosaic virus. Some of these compounds show notable activity.

Pharmacological studies of some 2-methyl-3-(arylthio-carbamido) quinazol-4-ones and 2-methyl-3-(aryliden-carboxamido) quinazol-4-ones

Some quinazolone derivatives of 2-methyl-3-(arylthio-carbamido)quinazol-4-ones 2 and 2-methyl-3-(aryliden-carboxamido) quinazol-4-ones 3 have been synthesised and assayed for their possible antibacterial activity against Bacillus subtilis, Bacillus cereus, Solmonella aureus, Solmonella lutae and antiviral activity against Gomphrena mosaic virus. Some of these compounds show notable activity.

Synthesis of Quinazolinylpyrimidinediones and Their Anti-inflammatory Activity

Hexahydro-1--3-aryl-2-thioxopyrimidine-4,6-diones (IV) have been prepared and converted into hexahydro-1--3-aryl-5-benzyliden-2-thioxopyrimidine-4,6-diones (V) and hexahydro-1-2-alkyl-4(