96897-96-0

Upstream product

• 124-38-9 carbon dioxide 
• 38064-90-3 2,4-dimethoxytoluene 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 98527-18-5 5-chloro-3-methyl-2,6-dimethoxybenzoic acid 
• 98527-21-0 5-bromo-3-methy-2,6-dimethoxybenzoic acid 
• 1421692-62-7 tert-butyl 2-(2,6-dimethoxy-3-methylphenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 96897-90-4 N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-2,6-dimethoxy-3-methyl-benzamide 
• 96897-92-6 N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-3-methyl-benzamide 
• 221552-14-3 2,5-dichloro-3-(3-chloro-2,6-dimethoxy-5-methyl-benzoyl)-pyrrole-1-carboxylic acid tert-butyl ester 
• 221552-16-5 (3-chloro-6-hydroxy-2-methoxy-5-methyl-phenyl)-(2,5-dichloro-1H-pyrrol-3-yl)-methanone 
• 221552-15-4 (3-chloro-2,6-dimethoxy-5-methyl-phenyl)-(2,5-dichloro-1H-pyrrol-3-yl)-methanone 
• 98527-33-4 3-Chloro-2,6-dimethoxy-5-methyl-benzoyl chloride 

Relevant academic research and scientific papers

The first total synthesis of pyralomicin 2c

Pyralomicin 2c (2) has been synthesized by N-glucosylation of the aglycone 16, which was prepared from the appropriately substituted pyrrole and benzoyl chloride (5 and 9).

Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides

A series of substituted 6-methoxysalicylamides were synthesized from their corresponding 2,6-dimethoxybenzamides by demethylation of one methoxy group with boron tribromide. Substituted 6-methoxysalicylamides having a lipophilic aromatic substituent in the 3-position para with respect to the methoxy group, e.g. a bromo or an iodo atom or an ethyl or a propyl group, and having an (S)-N-(1-alkyl-2-pyrrolidinyl)methyl moiety as the side chain were found to be potent blockers of [3H]spiperone binding in vitro and potent inhibitors of the apomorphine syndrome in the rat. Similar to remoxipride but in contrast to haloperidol, some of the substituted salicylamides show a 10-20 fold separation between the dose that inhibits hyperactivity and that which inhibits stereotypy. It was concluded that, besides the requirement of a lipophilic substitutent in the position para to the methoxy group for antidopamine activity in vivo, the formation of a coplanar six-membered pseudoring involving the amide moiety and the methoxy group is a structural requirement for activity in vitro.