96901-91-6Relevant academic research and scientific papers
Preparation method of elviravir
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Paragraph 0092-0095, (2021/04/17)
The invention provides a preparation method of elviravir, and belongs to the technical field of medicine preparation. According to the method, 2, 4-dimethoxybenzoic acid is used as a raw material and is sequentially subjected to a bromination reaction, an
TRIAZOLE DERIVATIVE AS AN HSP 90 INHIBITOR
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Page/Page column 13, (2010/05/13)
5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
Total synthesis of psoralidin, an anticancer natural product
Pahari, Pallab,Rohr, Juergen
supporting information; experimental part, p. 2750 - 2754 (2009/08/15)
A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.
PROCESS FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND
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Page/Page column 51, (2009/12/28)
The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifi
TRIAZOLE DERIVATIVES
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Page/Page column 68, (2008/06/13)
The invention relates to novel triazole derivatives of formula (I) wherein R1 - R6 and Y have the designations cited in patent claim 1. Said derivatives are HSP90 inhibitors, and can be used to produce a medicament for treating diseases wherefore the inhibition, regulation and/or modulation of HSP90 plays an important role.
Potential antipsychotic agents. 6. Synthesis and antidopaminergic properties of substituted N-(1-benzyl-4-piperidinyl)salicylamides and related compounds. QSAR based design of more active members
De Paulis,Hall,Kumar,Ramsby,Ogren,Hogberg
, p. 507 - 517 (2007/10/02)
A number of substituted 2-methoxybenzamides, with and without 6-hydroxy groups, with 4-piperidinyl side-chains have been synthesized and evaluated for their antidopaminergic properties. The salicylamides were found to require a lipophilic N-substituent, like a benzyl group, for high affinity for the dopamine D-2 binding site in contrast to salicylamides with 2-pyrrolodinylmethyl side-chains. Furthermore, the influence of the aromatic substituents on the activity in the 2 series, ie 4-piperidinyl and 2-pyrrolidinylmethyl side-chains, was different. This was supported by a Hansch analysis, which could accomodate both phenolic and non-phenolic benzamides with 1-benzyl-4-piperidinyl side-chains. The activity is primarily dictated by electronic features rather than by steric and lipophilic properties. The QSAR equations were validated by the design and synthesis of a new 10-fold more active derivative. The 2 classes of benzamides with different side-chains are suggested to act on different binding sites or on different subtypes of the dopamine D-2 receptor.
Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study
Hogberg,De Paulis,Johansson,Kumar,Hall,Ogren
, p. 2305 - 2309 (2007/10/02)
(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide (6) and some related compounds, i.e. the R isomer 7, the 3-hydroxy analogue 8, the desbromo derivative 9, the monomethoxy compound 10, and the 2,4-dimethoxy analogue 11, have been synth
