96917-43-0

Basic information

• Product Name: C₂₂H₂₆FNO₄
• CAS NO: 96917-43-0
• Molecular Weight: 387.451
• Mol File: 96917-43-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆FNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆FNO₄(96917-43-0)
• EPA Substance Registry System: C₂₂H₂₆FNO₄(96917-43-0)

Safety Data

• Hazardous Substances Data: 96917-43-0(Hazardous Substances Data)

Upstream product

• 94696-55-6 3-acetoxy-6α-<<(trifluoromethyl)sulfonyl>oxy>-14-hydroxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan 
• 16590-41-3 Naltrexone 
• 59888-62-9 3-acetoxy-6α,14-dihydroxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan 
• 100678-48-6 6β-naltrexol 

Relevant articles and documents

Probes for narcotic receptor mediated phenomena. 11. Synthesis of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-fluoromorphinans (foxy and cyclofoxy) as model of opioid ligands suitable for positron emission transaxial tomography

Fluorinated derivatives 3,14-dihydroxy-4,5α-epoxy-6β-fluoro-17-methylmorphinan ("fluorooxymorphone": FOXY, 10) and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-fluoromorphnian (CYCLOFOXY, 18) were prepared based upon the structures of the potent opioid agonist oxymorphone 4 and the antagonist naltrexone 11 respectively.Fluorine was introduced in the final stages of synthesis by a facile nucleophilic displacement with fluoride ion of the 6α-triflate functions in 8 and 16.The synthetic procedures are suitable for the production of the corresponding positron emitting 18F-labeled analogs 18F-FOXY and 18F-CYCLOFOXY, which may be usefuf for in vivo studies of the opioid receptor system using positron emission transaxial tomography.In addition, the tritiation of FOXY (10) to high specific activity is described