96919-49-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophen-3-yl-phenylamine is used as a chemical intermediate for the synthesis of various pharmaceuticals and organic compounds. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry by providing a versatile structure that can be modified to target specific diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-thiophen-3-yl-phenylamine is utilized for its potential applications in the creation of novel drug candidates. Its unique structure allows for the exploration of new chemical entities that can interact with biological targets, offering potential therapeutic benefits for various medical conditions.
Used in Materials Science:
2-Thiophen-3-yl-phenylamine may also find applications in materials science, where its chemical properties could be leveraged to develop new materials with specific characteristics, such as conductivity or stability, that are valuable in various technological applications.
Used in Agrochemicals:
2-THIOPHEN-3-YL-PHENYLAMINE's potential applications extend to the agrochemical industry, where it could be employed in the development of new pesticides or other agricultural chemicals, thanks to its unique chemical structure and properties that may offer advantages over existing products.

Upstream product

• 96919-48-1 3-(o-nitrophenyl)thiophene 
• 577-19-5 2-nitrophenyl bromide 
• 6165-69-1 Thien-3-ylboronic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 2404-87-7 3-phenylthiophene 
• 1341197-63-4 4-(4-methoxy-phenyl)thieno-[2,3-c]quinoline 
• 233-04-5 thieno[2,3-c]quinoline 
• 1254221-31-2 trimethyl((2-(thiophen-3-yl)phenyl)ethynyl)silane 

Relevant academic research and scientific papers

Metal- and additive-free cascade trifluoroethylation/cyclization of organic isoselenocyanates by phenyl(2,2,2-trifluoroethyl)iodonium triflate

A novel and convenient cascade trifluoroethylation/cyclization of organic isoselenocyanates by phenyl(2,2,2-trifluoroethyl)iodonium triflate is reported. A series of 2-isoselenocyanobiaryls and aryl alkyl isoselenocyanates reacted with phenyl(2,2,2-trifluoroethyl)iodonium triflate in CH2Cl2 at 40 °C under metal- and additive-free conditions for 3 h to provide the corresponding trifluoroethylselenolated phenanthridines and 3,4-dihydroisoquinoline derivatives in good to excellent yields. The reaction represents the first general approach to access trifluoroethylselenolated phenanthridines and 3,4-dihydroisoquinolines from organic isoselenocyanates.

Cobalt-Catalyzed C(sp2)-H Allylation of Biphenyl Amines with Unbiased Terminal Olefins

Unactivated olefins usually react poorly in conventional alkenylation reactions. Their introduction via C-H activation is limited to aromatic acids. Herein, we disclose a C-H functionalization protocol of aromatic amines with unactivated olefins, which shows exclusive allylic selectivity for the distal ring of the biphenyl system by exploiting a readily available cobalt(II) catalyst. The allylation proceeds smoothly involving a broad set of unbiased olefins and biaryls, giving access to the functionalization of the biphenyl scaffold.

TfOH-Promoted Transition-Metal-Free Cascade Trifluoroethylation/Cyclization of Organic Isothiocyanates by Phenyl(2,2,2-trifluoroethyl)iodonium Triflate

An efficient and transition-metal-free method for the synthesis of the structurally diversified trifluoroethylthiol phenanthridines and 3,4-dihydroisoquinolines is described. Various 2-isothiocyanobiaryls and aryl alkyl isothiocyanates reacted with phenyl(2,2,2-trifluoroethyl)iodonium triflate in CH2Cl2 in the presence of trifluoromethanesulfonic acid at 40 °C to form the corresponding trifluoroethylation/cyclization products in good to quantitative yields. This work represents the first construction of trifluoroethylthiol phenanthridine and isoquinoline derivatives from isothiocyanates in the absence of transition-metal catalysts by a one-pot procedure.

Boroquinol Complexes with Fused Extended Aromatic Backbones: Synthesis and Optical Properties

Boron-based dyes are attractive synthetic targets due to their large variability of absorption and emission wavelengths. Through Pictet–Spengler cyclizations, followed by oxidation, π-extended boroquinols have been synthesized. During optimization of the

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process

An efficient, highly regio- and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new C?C bonds through double carbopalladation and C?H activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9H-pyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores. (Figure presented.).

Visible-light-induced regioselective synthesis of polyheteroaromatic compounds

A method for visible-light-induced synthesis of polyheteroaromatics from 2-heteroaryl-substituted anilines and heteroarylalkynes was developed. The process, which uses fac-Ir(ppy)3 as the photocatalyst and tBuONO as the diazotization reagent, is highly regioselective.

NON-PEPTIDIC NEUROPEPTIDE Y RECEPTOR MODULATORS

The invention provides compounds that are modulators of neuropeptide Y (NPY) receptors, which can be selective inhibitors of NPY receptor Y2R. NPY receptor modulatory compounds are of the general formula Ar2-Y-Ar1-W-Ar3, wherein the variables are as defined herein. Compounds of the invention can be used for treatment of malconditions in patients wherein modulation of an NPY receptor is medically indicated, for example including drug or alcohol abuse, anxiety disorders, depression, stress-related disorders, neurological disorders, nerve degeneration, osteoporosis or bone loss, sleep/wake disorders, cardiovascular diseases, obesity, anorexia, inovulation, fertility disorders, angiogenesis, cell proliferation, learning and memory disorders, migraine and pain.

INTRAMOLECULAR DIAZO COUPLING OF 2-AMINOPHENYLTHIOPHENES. THE FORMATION OF ISOMERIC THIENOCINNOLINES

Thieno- (4) and thieno-cinnolines (7) have been obtained by diazotisation and internal coupling of the corresponding 2-(o-aminophenyl)thiophenes.By the same reaction 3-(o-aminophenyl)-2,5-dimethylthiophene gives 1,3-dimethylthienolcinnoline (9).