96928-20-0

Basic information

• Product Name: 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester
• CAS NO: 96928-20-0
• Molecular Weight: 398.483
• Mol File: 96928-20-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester(96928-20-0)
• EPA Substance Registry System: 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester(96928-20-0)

Safety Data

• Hazardous Substances Data: 96928-20-0(Hazardous Substances Data)

Upstream product

• 96928-09-5 ethyl 2-(4-acetylphenoxy)-propanoate 
• 91143-71-4 (RS)-2-(4-acetylphenoxy)propionic acid 
• 80099-46-3 ethyl 2-[4-(2-bromoacetyl)phenoxy]-propanoate 
• 2293-07-4 1-(4-methoxyphenyl)thiourea 

Downstream Products

• 96928-29-9 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid 

Relevant articles and documents

Synthesis and Mass Spectral Studies of Some Thiazolylphenoxypropionic Acids and Esters

Several 2- and 3-propionic acids (III and IV) have been prepared by the reaction of the corresponding phenacyl bromides with thioureas and thioamides (Hantzsch synthesis).The mass spectra of the esters (II) of III show a unique fragmentation resulting in the concerted loss of CH3CHO and CH3CH=C=O from the molecular ion through a rearrangement involving transfer of a hydrogen atom from ethyl group to the phenoxy oxygen.Another hydrogen transfer reaction leads to the concerted loss of CO2 and C2H4 from the molecular ion of IV.However, no such process is observed in the mass spectra of III.The thiazole ring suffers cleavage in a characteristic manner after the removal of acid/ester function in II, III and IV.The compounds have been screened for their antiinflammatory activity.