91143-71-4

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-ACETYLPHENOXY)PROPANOIC ACID is used as a cholesterol-lowering agent for the treatment of high cholesterol and high triglycerides. It is employed to reduce the production of triglycerides in the liver and increase their elimination from the blood, thereby helping to manage and lower lipid levels in patients with dyslipidemia.
Used in Cardiovascular Health:
2-(4-ACETYLPHENOXY)PROPANOIC ACID is used as a therapeutic intervention to improve cardiovascular health by reducing the risk of atherosclerosis and related complications. Its lipid-lowering effects contribute to the prevention of plaque buildup in the arteries, which can lead to heart disease and stroke.
Used in Medical Treatment:
2-(4-ACETYLPHENOXY)PROPANOIC ACID is used as a medication for patients with conditions such as hypertriglyceridemia and hypercholesterolemia. It is prescribed to help regulate lipid metabolism and decrease the risk of cardiovascular events in individuals with these lipid disorders.

InChI:InChI=1/C11H12O4/c1-7(12)9-3-5-10(6-4-9)15-8(2)11(13)14/h3-6,8H,1-2H3,(H,13,14)/p-1/t8-/m1/s1

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 91497-60-8 methyl 2-(4-acetylphenoxy)propionate 
• 96928-09-5 ethyl 2-(4-acetylphenoxy)-propanoate 

Downstream Products

• 13794-00-8 2-(4-acetylamino-phenoxy)-propionic acid 
• 96928-20-0 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester 
• 96928-21-1 2-{4-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester 
• 96928-19-7 2-[4-(2-p-Tolylamino-thiazol-4-yl)-phenoxy]-propionic acid ethyl ester 
• 96928-29-9 2-{4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-propionic acid 
• 96928-18-6 2-[4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-propionic acid ethyl ester 
• 96928-25-5 2-{4-[2-(4-Methoxy-phenyl)-thiazol-4-yl]-phenoxy}-propionic acid ethyl ester 
• 96928-28-8 2-[4-(2-p-Tolylamino-thiazol-4-yl)-phenoxy]-propionic acid 
• 96928-27-7 2-[4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-propionic acid 
• 96928-34-6 2-{4-[2-(4-Methoxy-phenyl)-thiazol-4-yl]-phenoxy}-propionic acid 
• 96928-24-4 2-[4-(2-p-Tolyl-thiazol-4-yl)-phenoxy]-propionic acid ethyl ester 
• 96928-23-3 2-[4-(2-Phenyl-thiazol-4-yl)-phenoxy]-propionic acid ethyl ester 
• 96928-33-5 2-[4-(2-p-Tolyl-thiazol-4-yl)-phenoxy]-propionic acid 
• 96928-32-4 2-[4-(2-Phenyl-thiazol-4-yl)-phenoxy]-propionic acid 

Relevant academic research and scientific papers

Microbial deracemization of α-substituted carboxylic acids: Substrate specificity and mechanistic investigation

A new enzymatic method for the preparation of optically active α-substituted carboxylic acids is reported. This technique is called deracemization reaction, which provides us with a route to obtain the enantiomerically pure compounds, theoretically in 100% yield starting from the racemic mixture. This means that the synthesis of a racemate is almost equal to the synthesis of the optically active compound, and this concept is entirely different from the commonly accepted one in the asymmetric synthesis. Using the growing cell system of Nocardia diaphanozonaria JCM3208, racemates of 2-aryl- and 2-aryloxypropanoic acid are deracemized smoothly and (R)-form-enriched products are recovered in high chemical yield (>50%). In addition, using optically active starting compounds and deuterated derivatives as well as inhibitors, we have disclosed the fact that a new type of enzyme takes part in this biotransformation, and that the reaction proceeds probably via the same mechanism as that in rat liver.

Synthesis of 2-(4-hydroxyphenoxy)alkanoic acids

A method for synthesizing 2-(4-hydroxyphenoxy)alkanoic acids by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid under basic conditions and thereafter oxidizing the intermediate with subsequent hydrolysis.

Synthesis of 2-(4-aminophenoxy)alkanoic acids and esters and their derivatives

A method for synthesizing 2-(4-amidophenoxy)alkanoic acids and esters and 2-(4-aminophenoxy)alkanoic acids and esters by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid or ester under basic conditions and thereafter reactin