96963-49-4

Upstream product

• 443638-87-7 N-(3-methylbenzoyl)-8-aminoquinoline 
• 134-32-7 1-amino-naphthalene 

Downstream Products

• 1293990-77-8 7-methyl-2,3-diphenylisoquinolin-1(2H)-one 
• 52712-17-1 2-(m-tolyl)naphtho[1,2-d]thiazole 
• 96963-37-0 3-Methyl-N-naphthalen-1-yl-thiobenzamide 

Relevant academic research and scientific papers

An efficient, one-pot transamidation of 8-aminoquinoline amides activated by tertiary-butyloxycarbonyl

The efficient, one-pot access to the transamidation of 8-aminoquinoline (8-AQ), notorious for its harsh removal conditions, has been widely employed as an auxiliary in C–H functionalization reactions due to its strong directing ability. In this study, the facile and mild Boc protection of the corresponding 8-AQ amide was critical to activate the amide C(acyl)–N bond by twisting its geometry to lower the amidic resonance energy. Both aryl and alkyl amines proceeded transamidation in one-pot, user-friendly conditions with excellent yields.

Amide Boc de-protection method

The invention discloses an amide Boc de-protection method. The amide Boc de-protection method includes carrying out reaction on Boc protected amide III and amine IV under the condition of the presenceof palladium catalysts to generate new amide V. 8-aminoquinoline can be used as a guide group to be applied to chemical reaction, a process for synthesizing the new amide by means of de-protection isprovided, protecting groups can be easily removed by means of palladium catalysis, the new amide can be generated, and the reaction is high in efficiency. The amide Boc de-protection method has the advantages of environmental friendliness, recyclability and the like.