96988-65-7Relevant academic research and scientific papers
Vinyl selenones: Annulation agents for the synthesis of six-membered benzo-1,4-heterocyclic compounds
Bagnoli, Luana,Casini, Sara,Marini, Francesca,Santi, Claudio,Testaferri, Lorenzo
, p. 481 - 486 (2013/02/23)
A novel and general approach to six-membered bicyclic benzo fused 1,4-heterocycles is described. The addition-cyclization cascade of benzo 1,2-diols, 1,2-thiols and 2-(benzylamino)phenols with stable and easily available vinyl selenones affords differently substituted 2,3-dihydro-1,4- benzodioxines, benzodithiines and 3,4-dihydro-2H-1,4-benzoxazines in good yields. The same procedure has been extended to the synthesis of 1,2,3,4-tetrahydroquinoxalines. All of these heterocycles are present in a variety of biologically active compounds.
Synthesis of substituted 4-(3-alkyl-1,2,4-oxadiazol-5-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines and 4-(1H-benzimidazol-2-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines
Mizar, Pushpak,Myrboh, Bekington
, p. 7823 - 7826 (2007/10/03)
Substituted 2H-1,4-benzoxazines were synthesized from substituted 2-amino phenols and 1,2-dibromoethane using K2CO3 in good to excellent yields. The cyclized products were further reacted with alkyl bromides to obtain the desired N-substituted 3,4-dihydro-2H-1,4-benzoxazines.
Efficient nickel-mediated intramolecular amination of aryl chlorides
Omar-Amrani, Rafik,Thomas, Antoine,Brenner, Eric,Schneider, Raphael,Fort, Yves
, p. 2311 - 2314 (2007/10/03)
(Matrix presented) The use of an in situ generated Ni(0) catalyst associated with 2,2′-bipyridine or N,N′ -bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings.
