845829-94-9

Basic information

• Product Name: 2-Bromo-6-fluoroanisole
• Synonyms: 2-BROMO-6-FLUOROANISOLE;1-BROMO-3-FLUORO-2-METHOXY-BENZENE;Benzene, 1- bromo- 3- fluoro- 2- methoxy-
• CAS NO: 845829-94-9
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• EINECS: 679-553-0
• Product Categories: Benzene series;Benzenes
• Mol File: 845829-94-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 208.587 °C at 760 mmHg
• Flash Point: 94.379 °C
• Appearance: /
• Density: 1.532 g/cm³
• Vapor Pressure: 0.306mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-6-fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-fluoroanisole(845829-94-9)
• EPA Substance Registry System: 2-Bromo-6-fluoroanisole(845829-94-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 845829-94-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to pale yellow liquid

Uses

2-Bromo-6-fluoroanisole is a reactant in the preparation of quinazolines as a c-jun N-terminal kinase (JNK) inhibitor with good brain penetration.

InChI:InChI=1/C7H6BrFO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3

Upstream product

• 875664-44-1 C₇H₇BrFNO 
• 374633-24-6 1-bromo-2,3-difluoro-5-nitrobenzene 
• 369-34-6 3,4-difluoronitrobenzene 
• 2040-89-3 2-bromo-6-fluorophenol 
• 74-88-4 methyl iodide 
• 367-12-4 2-fluorophenol 
• 484-94-6 1-fluoro-2-methoxy-3-nitrobenzene 
• 1526-17-6 2-fluoro-6-nitrophenol 
• 437-83-2 3-fluoro-2-methoxyaniline 

Downstream Products

• 1426073-33-7 4-bromo-2-fluoro-3-methoxybenzonitrile 
• 194804-99-4 ethyl 3-(4-bromo-2-fluoro-3-methoxyphenyl)-3-oxopropionate 
• 194804-92-7 4-bromo-2-fluoro-3-methoxybenzoic acid 
• 1049729-85-2 3-fluoro-2-methoxybenzenesulfonyl chloride 
• 1121613-46-4 C₁₁H₁₅FN₂O 
• 628330-77-8 methyl 2-(3-fluoro-2-hydroxyphenyl)acetate 

Relevant articles and documents

Preparation method of 2-bromo-6-fluoroanisole

The invention discloses a preparation method of 2-bromine-6-fluoroanisole, the preparation method comprises the following specific steps: (1) carrying out electrophilic substitution reaction on 3, 4-difluoronitrobenzene and bromosuccinimide to generate a compound III; (2) reacting the compound III with sodium methoxide to generate a compound IV; (3) reducing the compound IV by sodium hydrosulfite to generate a compound V; (4) performing diazotization deamination on the compound V to generate a compound I; the obtained product is 2-bromo-6-fluoroanisole. The preparation method is higher in yield.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula(I) or a pharmaceutically acceptable salt thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.