96994-71-7Relevant academic research and scientific papers
Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors
Kim, Ho Shin,Hong, Mannkyu,Lee, Su-Chan,Lee, Ho-Young,Suh, Young-Ger,Oh, Dong-Chan,Seo, Ji Hae,Choi, Hoon,Kim, Jun Yong,Kim, Kyu-Won,Kim, Jeong Hun,Kim, Joohwan,Kim, Young-Myeong,Park, So-Jung,Park, Hyun-Ju,Lee, Jeewoo
, p. 157 - 164 (2015)
A series of fluorophenyl and pyridine analogues of 1 and 2 were synthesized as ring-truncated deguelin surrogates and evaluated for their HIF-1α inhibition. Their structure-activity relationship was systematically investigated based on the variation of th
Catechol derivatives
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, (2008/06/13)
Catechol derivatives of the formula STR1 wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuable pharmacological properties. In particular, they inhibit the enzyme catechol-O-methyltransferase (COMT), a soluble, magnesium-dependent enzyme which catalyses the transference of the methyl group of S-adensoylmethionine to a catechol substrate, whereby the corresponding methyl ethers are formed. Suitable substrates which can be O-methylated by COMT and which can thus be deactivated are, for example, extraneuornal catecholamines and exogeneously-administered therapeutically active substances having a catechol structure. Formula Ia above embraces not only compounds which form part of the invention, but also known compounds; the compounds which form part of the invention can be prepared according to known methods.
