96994-74-0

Upstream product

• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 124-40-3 dimethyl amine 
• 588-07-8 3-Chloroacetanilide 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 611-06-3 2,4-dichloronitrobenzene 
• 1635-61-6 5-chloro-2-nitroaniline 
• 77-78-1 dimethyl sulfate 
• 160938-18-1 1-iodo-5-chloro-2-nitrobenzene 
• 63860-31-1 2-bromo-4-chloro-1-nitrobenzene 
• 64-17-5 ethanol 

Relevant academic research and scientific papers

BENZIMIDAZOLE COMPOUNDS

There is provided a compound of the formula (1) wherein R1 is an optionally substituted C1-10 alkyl; R2 is H, or a C1-6 alkyl which may be substituted with 1 to 3 substituents; R3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6- membered ring which may be substituted with 1 to 3 C1-6 alkyls; R4 is a hydrogen, a halogen, a hydroxy, a cyano, a C1-6 alkyl or a C1-6 alkoxy; Z is -O-, -S-, -SO-, -SO2-, or - NR5- wherein R5 is a hydrogen or a C1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

THE REACTION OF ACTIVATED ARYL AND HETEROARYL DIHALIDES WITH HMPA. A REGIOSELECTIVITY STUDY

A series of activated aryl and heteroaryl dihalides were reacted with HMPA at elevated temperatures.Of the eleven examples studied, all but one reacted in a regioselective manner to give a monohalo-N,N-dimethylamino derivative.