96997-82-9

Upstream product

• 129001-06-5 (R)-2-Chlorocarbonyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester 
• 125736-03-0 (R)-9-Aza-bicyclo[4.2.1]nonane-2,9-dicarboxylic acid 9-tert-butyl ester 
• 125736-06-3 (1R,2R)- and (1R,2S)-9-(tert-butoxycarbonyl)-2-(methoxycarbonyl)-9-azabicyclo<4.2.1>nonane 
• 129001-05-4 C₁₇H₂₇NO₄S₂ 
• 1121-30-8 1-hydroxy-2(1H)-pyridinethione 
• 129001-07-6 (1R,2R,5R,S)-5-acetyl-9-(tert-butoxycarbonyl)-2-carboxy-9-azabicyclo<4.2.1>nonane 
• 129001-01-0 (1R,2R)-5-Acetyl-9-aza-bicyclo[4.2.1]nonane-2,9-dicarboxylic acid 9-tert-butyl ester 2-methyl ester 
• 133038-46-7 ethyl 2-(methoxycarbonylamino)hepta-5,6-dienoate 
• 111964-06-8 3-(methylsulphonyl)-9-(p-tolylsulphonyl)-9-azabicyclo<4.2.1>nonan-2-one 
• 133038-55-8 cis-2-(2-hydroxyethyl)-1-(p-tolylsulphonyl)-5-<(methylsulphonyl)acetyl>pyrrolidine 
• 111964-05-7 cis 2-(2-bromoethyl)-5-<(methylsulphonyl)acetyl>-1-(p-tolylsulphonyl)pyrrolidine 
• 107970-41-2 ethyl 2-(p-tolylsulphonylamino)hepta-5,6-dienoate 
• 111964-04-6 cis-(p-tolylsulphonyl)-5-vinylproline ethyl ester 
• 133038-54-7 cis-5-(2-hydroxyethyl)-1-(p-tolylsulphonyl)proline ethyl ester 

Downstream Products

• 90741-53-0 (1R)-2-acetyl-9-(1-tert-butoxycarbonyl)-9-azobicyclo<4.2.1>-2-nonene 

Relevant academic research and scientific papers

Synthetic and Stereochemical Studies Directed Towards Anatoxin-a

The synthesis and stereocontrolled Ag1-catalysed cyclisation of a series of allenic amino esters 8a-e is described.For compounds 8a-d the cis-2,5-disubstituted pyrrolidine 9 is formed exclusively but the primary amine 8e undergoes cyclisation n

Enantiodivergent Synthesis of (+)- and (-)-Anatoxin from L-Glutamic acid

The optically pure 2,5-difunctionalized homotropane 11, prepared from L-glutamic acid, serves as the common, advanced intermediate for the synthesis of either natural (+)-anatoxin (30, 18percent overall yield) or unnatural (-)-anatoxin (33, 30percent overall yield) by selective manipulation of either the C-2 ester or C-5 acetyl functionalities.Side-chain substitution in the decarbonylative iminium ion cyclization of a substituted proline enhanced the yield by 25percent as compared to the unsubstituted parent system.The additional substitution at C-5 of the 9-azabicyclononane ring system allows access to analogues of anatoxin not availalble through other syntheses.