970-86-5Relevant academic research and scientific papers
Non-Glycosidic and Non-Peptidic Select Inhibitors, and the Use Thereof
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, (2008/06/13)
A new class of non-glycosidic and non-peptidic inhibitors of selectins with low molecular weight according to the general formula 1 is described, as well as methods for their production. These compounds represent a new class of non-toxic, in vivo anti-inf
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
Ulbrich, Holger K.,Luxenburger, Andreas,Prech, Philip,Eriksson, Einar E.,Soehnlein, Oliver,Rotzius, Pierre,Lindbom, Lennart,Dannhardt, Gerd
, p. 5988 - 5999 (2007/10/03)
An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy LewisX is a ligand for E-, P-, and L-selectin and therefore serve
NON-GLYCOSIDIC AND NON-PEPTIDIC SELECT INHIBITORS, AND THE USE THEREOF
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Page/Page column 26, (2008/06/13)
The invention relates to a category of non-glycosidic and non-peptidic select inhibitors of general formula (1), with a low molecular weight, and to a method for the production thereof. Said category is a category of non-toxic select inhibitors having an
Observation of intramolecular dimer radical anion of 1,1-diarylmethanols bearing electron withdrawing groups at room temperature
Ichinose, Nobuyuki,Hobo, Junpei,Tojo, Sachiko,Majima, Tetsuro
, p. 97 - 102 (2007/10/03)
Transient absorption measurement of radical anions of 1,1-diarylmethanols bearing electron-withdrawing groups in dimethyl-formamide at room temperature has revealed that symmetric compounds form intramolecular dimer radical anions as an intermediate of th
SYNTHESIS OF JUVABIONE ANALOGUES
Mane, Ramchandra B.,Desai, Uday V.,Hebbalkar, Geeta D.
, p. 646 - 657 (2007/10/02)
Alkylation of various β-ketoesters IIIa-d with bis(p-methoxycarbonylphenyl)bromomethane (II) and bis(p-chlorophenyl)bromomethane (VI) followed by cleavage of ethoxycarbonyl group or hydrolysis and esterification gave methoxycarbonylphenyl and chlorophenyl analogues of ar-juvabione, respectively.Condensation of bis(p-methoxycarbonylphenyl)methanol (IX) with isovaleryl and trichloroacetyl chloride gave isovalerate X and trichloroacetate XI, respectively, while the condensation of bis(p-chlorophenyl)methanol (XII) with isovaleryl chloride and citronellyl bromide yieldedisovalerate XIII and citronellyl ether XIV, respectively.The methoxycarbonylation of aryl-alkyl ketones XVa-d with oxalyl chloride and treatment with methanol furnished various ar-juvabione analogues XVIa-d.The compounds Vb, Vc, Vd, XVIb, and XVIc showed high activity against Dysdercus koenigii at 1μg concentration.
