97006-42-3

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 2826-28-0 p-(N-dimethylamino benzylidene) malononitrile 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 40029-47-8 2-cyano-3-[4-(dimethylamino)phenyl]propanamide 
• 27781-35-7 2,3-dicyano-3t-(4-dimethylamino-phenyl)-acrylic acid amide 

Relevant academic research and scientific papers

Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles

A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit

Tetra-n-butylammonium hydroxide (TBAH)-catalyzed Knoevenagel condensation: A facile synthesis of α-cyanoacrylates, α-cyanoacrylonitriles, and α-cyanoacrylamides

Tetra-n-butylammonium hydroxide (TBAH) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as methyl- and ethylcyanoacetate, malononitrile, and cyanoacetamide to afford sub

Solvent-free Knoevenagel condensations and Michael additions in the solid state and in the melt with quantitative yield

Numerous Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyanoacetate in stoichiometric mixtures of the solids or of stoichiometri

Potassium exchanged layered zirconium phosphate as base catalyst in Knoevenagel condensation

Potassium exchanged layered zirconium phosphate catalyzed Knoevenagel condensation of aldehydes and active methylene compounds gave the corresponding E configurated olefinic derivatives in solvent free conditions.

Synthetic approaches towards benzo[h]quinoline-3-carbonitriles

2-Alkoxybenzo[h]quinoline-3-carbonitriles 2 were readily synthesized via Dimroth rearrangement of 2-amino-4-aryl-5,6-dihydro-4H-naphtho[1,2-b]pyran-3- carbonitriles 5 induced by ethanolic and methanolic KOH. Compounds 2 were also obtained by the reaction of 2-arylmethylidene-3,4-dihydro-1(2H)- naphthalenones 1 with malononitrile or of ylidenemalononitriles 4 with 1,2,3,4-tetrahydro-1-naphthalenone in ethanolic and methanolic KOH. The molluscicidal activity of the products towards Biomphalaria alexandrina snails was screened.

Knoevenagel condensation in heterogeneous phase catalyzed by IR radiation and Tonsil Actisil FF

Infrared radiation promoted the synthesis of benzylidenemalononitriles, benzylidenecyanoacetamides and benzylidenecyanoacetic acids by condensation of aromatic aldehydes with the corresponding active methylene compound in the presence of Tonsil Actisil FF, without solvent. Mass of catalyst, solvent, and reaction time were assessed in order to improve the efficiency of this process.