2826-28-0Relevant articles and documents
Dendrimer-Functionalized Magnetic Graphene Oxide for Knoevenagel Condensation
Maleki, Behrooz,Taheri, Fatemeh,Tayebee, Reza,Adibian, Fatemeh
, p. 284 - 290 (2021)
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Malononitrile–derivative chromogenic devices for the detection of cyanide in water
Schramm, Adriana D.S.,Menger, Renata,Machado, Vanderlei G.
, p. 811 - 818 (2016)
Two compounds, 2–(4–hydroxybenzylidene)malononitrile (1a) and 2–[4–(dimethylamino)benzylidene]malononitrile (2), were synthesized with a view to their use as optical devices for anionic detection. Compound 1a was studied as a chromogenic chemosensor using an acid–base strategy. In purely aqueous medium, 1a was used in the detection of CN? with high selectivity. This is possible because the colorless solution of the compound becomes yellow upon addition of the anion, which acts as a base and abstracts the hydrogen from the phenolic moiety of the molecule, generating the corresponding dye (1b). Optical detection and optical quantification limits were determined as 6.17?×?10??7?mol?L??1 and 2.06?×?10??6?mol?L??1, respectively. These values are much lower than the maximum level of the concentration of CN? allowed by the World Health Organization in potable water (1.7?μmol?L??1). Compound 2 was used in a chemodosimeter approach for the highly selective detection of CN? in water with cetyltrimethylammonium bromide above its critical micellar concentration. Solutions of 2 are yellow but become colorless with the addition of the anion. This is because CN? attacks the CH[dbnd]C double bond in the compound and disrupts the electronic conjugation between the electron donating and the electron accepting moieties of the dye. Thus, with the addition of CN? to the medium compound 1a acts as an off–on optical device while dye 2 operates as an on–off chemodosimeter.
Mesoporous titanosilicate Ti-TUD-1 catalyzed Knoevenagel reaction: An efficient green synthesis of trisubstituted electrophilic olefins
Karmakar, Bikash,Chowdhury, Biswajit,Banerji, Julie
, p. 601 - 605 (2010)
A new, efficient and green methodology has been developed for the Knoevenagel condensation using catalytic amount of mesoporous titanosilicate catalyst Ti-TUD-1, under mild conditions at room temperature. The method generates trisubstituted electrophilic olefins in high yields within short reaction time. The mesoporous nature of the catalyst having high surface area helps in binding the substrate to the active site. The advantage of this catalyst is its reusability with almost consistent reactivity thereby making it viable for industrial applications.
A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation
Ahmad, Rumana,Azad, Iqbal,Kamal, Azhar,Khan, Abdul Rahman,Khan, Tahmeena,Nasibullah, Malik
, (2020/11/24)
A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile derivatives (C1-C12) is proposed. Characterization of the derivatives was done by sup
Effect of supramolecular polymeric aggregation in room temperature ionic liquids (RTILs) on catalytic activity in the synthesis of 4H-chromene derivatives and Knoevenagel condensation
Muhammad, Shoaib,Ali, Firdous Imran,Javed, Muhammad Naveed,Wasim, Agha Arsalan,Bari, Ahmed,Rafique, Faisal,Ilyas, Muhammad Amjad,Riaz, Kashif,Mahmood, Syed Junaid,Ahmed, Amir,Hashmi, Imran Ali
, (2020/10/30)
RTILs exhibit supramolecular self-assembled polymeric aggregation due to noncovalent interactions. The influence of the aggregation behaviour of RTILs on catalytic activity is evident but still poorly understood. The present work focuses on establishing a