97021-21-1Relevant academic research and scientific papers
Ammonia in Ugi reactions - Four-component versus six-component couplings
Pick, Rigobert,Bauer, Michael,Kazmaier, Uli,Hebach, Christina
, p. 757 - 760 (2005)
If ammonia is used as amine component in Ugi reactions, the desired peptide sometimes is obtained only as the minor product or in traces. Side reactions such as six-component couplings are responsible for this observation. These side reactions can be suppressed or favoured depending on the reaction conditions used.
