97022-62-3Relevant academic research and scientific papers
Cyclic nucleotide-gated channel block by hydrolysis-resistant tetracaine derivatives
Andrade, Adriana L.,Melich, Kenneth,Whatley, G. Gregory,Kirk, Sarah R.,Karpen, Jeffrey W.
, p. 4904 - 4912 (2011)
To meet a pressing need for better cyclic nucleotide-gated (CNG) channel antagonists, we have increased the biological stability of tetracaine-based blockers by synthesizing amide and thioamide linkage substitutions of tetracaine (1) and a higher affinity
DERIVATIVES OF TETRACAINE
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, (2014/02/16)
Disclosed herein are derivatives of tetracaine that, among other things, block cyclic nucleotide gated (CNG) channels and are useful in the treatment of diseases characterized by overactive CNG channels such as retinal degeneration diseases.
