97025-97-3

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 66224-66-6 adenine 

Downstream Products

• 172405-17-3 N⁶-(4-methoxybenzoyl)-9-(methoxycarbonylmethyl)adenine 
• 312613-60-8 [6-(4-methoxy-benzoylamino)-purin-9-yl]-acetic acid tert-butyl ester 
• 479675-88-2 9-[4-(1,1-dimethylethoxycarbonylamino)benzyl]-N₆-(4-methoxybenzoyl)adenine 
• 534551-10-5 4-(1-hexyloxy-6-(N⁶-(4-methoxybenzoyl)adenine))-1-iodobenzene 
• 534551-06-9 4-(1-nonyloxy-6-(N⁶-(4-methoxybenzoyl)adenine))-1-iodobenzene 
• 172405-18-4 N⁹-(carboxymethyl)-N⁶-(4-methoxybenzoyl)adenine 
• 479675-89-3 9-[4-aminobenzyl]-N₆-(4-methoxybenzoyl)adenine 
• 479675-90-6 9-[4-(cholesterylcarbonylamino)benzyl]-N₆-(4-methoxybenzoyl)adenine 
• 263254-51-9 ([2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethyl]-{2-[6-(4-methoxybenzoylamino)purin-9-yl]acetyl}amino)acetic acid tert-butyl ester 
• 172405-39-9 methyl N-<2-((4-methoxyphenyl)-diphenylmethylamino)ethyl>-N-<(N⁶-(4-methoxybenzoyl)-adenin-9-yl)acetyl> glycinate 
• 1235489-05-0 C₂₁H₂₄N₆O₆ 

Relevant academic research and scientific papers

Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors

Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that bind to acetylated lysines in histones. Among them, BRD4 is a candidate target molecule of therapeutic agents for diverse diseases, including cancer and inflammatory disease.

Utilization of a combination of weak hydrogen-bonding interactions and phase segregation to yield highly thermosensitive supramolecular polymers

Supramolecular polymerization, i.e., the self-assembly of polymer-like materials through the utilization of the noncovalent bond, is a developing area of research. In this paper, we report the synthesis and investigation of nucleobase-terminated (N6

Fmoc/Acyl protecting groups in the synthesis of polyamide (peptide) nucleic acid monomers

The chemical synthesis of polyamide (peptide) nucleic acid (PNA) monomers 22-25 has been accomplished using Fmoc [N-(2-aminoethyl)glycine backbone], anisoyl (adenine), 4-tert-butylbenzoyl (cytosine) and isobutyryl/ diphenylcarbamoyl (guanine) protecting-group combinations, thus allowing oligomer synthesis on both peptide and oligonucleotide synthesizers. An alternative method for the preparation of (N6-anisoyladenin-9-yl)acetic acid 7 is described using partial hydrolysis of a dianisoylated derivative. Different methods were studied for guanine alkylation including (a) Mitsunobu reaction; (b) low-temperature, sodium hydride- and (c) N, N-diisopropylethylaminemediated alkylation reactions to give preferentially N9-substituted derivatives. Empirical rules are proposed for differentiating N9/N7-substituted guanines based on their 13C NMR chemical-shift differences. The Royal Society of Chemistry 2000.

Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids

There are described N-ethylglycine derivatives of the formula I in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH2, NH or O, and B' are bases customary in nucleotide chemistry, the exocyclic amino or hydroxyl groups of which being protected by suitable, known protective groups, or are base substitute compounds, and their salts with tert-organic bases, as well as a process for their preparation. The N-ethylglycine derivatives of the formula I are used in the preparation of PNA and PNA/DNA hybrids.

The synthesis of polyamide nucleic acids using a novel monomethoxytrityl protecting-group strategy

The preparation of novel monomethoxytrityl (Mmt) protected monomers for the synthesis of polyamide nucleic acids (PNAs) is described. The use of base-labile acyl-type nucleobase protecting groups and of a succinyl-linked solid-support offers a synthetic strategy to standard oligonucleotide synthesis conditions. This strategy has been successfully applied for the synthesis of PNAs of mixed base sequence.