97028-77-8Relevant academic research and scientific papers
4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules
Haskali, Mohammad B.,Farnsworth, Ashleigh L.,Roselt, Peter D.,Hutton, Craig A.
, p. 919 - 922 (2020/09/15)
Indirect radiolabelling has for a long time been the mainstay strategy for radiofluorination of biomolecules. Acylation of biomolecules through the use of an 18F-labelled activated ester is a standard method for indirect radiolabelling. However, the preparation of 18F-labelled activated esters is typically a complex and multistep procedure. Herein, we describe the use of 4-nitrophenyl (PNP) activated esters to rapidly prepare 18F-labelled acylation synthons in one step. Furthermore, we present a comparative study of PNP activated esters and the commonly utilised 2,3,5,6-tetrafluorphenyl (TFP) activated esters under direct radiofluorination conditions and demonstrate their relative acylation behaviour. We demonstrate the superiority of PNP esters under direct radiofluorination conditions with favourable acylation kinetics.
Agents for diagnosing and treating melanomas, aromatic halogenated derivatives usable as such agents and their preparation
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, (2008/06/13)
STR1 The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z--CONH--, Z--O--, Z--S(O)--n1 group, n1 being equal to 0,1,2 or 3
