97033-37-9Relevant academic research and scientific papers
Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors
Ku, Angela F.,Cuny, Gregory D.
, p. 353 - 356 (2018)
A series of (-)-nornuciferidine derivatives was synthesized and the non-natural enantiomer of the aporphine alkaloid was discovered to be a potent β1- and β2-adrenergic receptor ligand that antagonized isoproterenol and procaterol induced cyclic AMP increases from adenylyl cyclase, respectively. Progressive deconstruction of the tetracyclic scaffold to less complex cyclic and acyclic analogues revealed that the conformationally restricted (6a-R,7-R)-7-hydroxyaporphine 2 (AK-2-202) was necessary for efficient receptor binding and antagonism.
AN ENANTIOSELECTIVE SYNTHESIS OF 1-(α-HYDROXYALKYL)-1,2,3,4-TETRAHYDROISOQUINOLINES THROUGH OPTICALLY ACTIVE N-OXAACYLIMINIUM ION INTERMEDIATES
Kano, Shinzo,Yuasa, Yoko,Shibuya, Shiroshi
, p. 395 - 398 (2007/10/02)
An enantioselective synthesis of 1S-(1'S-hydroxyethyl)- 1S-(1'S-hydroxybenzyl)- and 1R-(1'R-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline was achieved by reductive cleavage of the oxazolidinone ring of the correspponding 1-substituted oxazoloisoqui
