97051-69-9

Usage

Uses

Used in Pharmaceutical Research and Development:
N1-[2-AMINO-4-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE is used as a key intermediate in the synthesis of potential drug candidates. Its trifluoromethyl group contributes to the enhancement of biological activity and metabolic stability of the resulting molecules, which is crucial for the development of effective pharmaceuticals.
Used in Agrochemicals:
In the agrochemical industry, N1-[2-AMINO-4-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE may be utilized as a component in the development of new pesticides or herbicides, leveraging its chemical properties to improve the effectiveness and stability of these products.
Used in Materials Science:
N1-[2-AMINO-4-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE could also be employed in materials science for the creation of novel materials with specific properties. The trifluoromethyl group might impart unique characteristics to the materials, making them suitable for various applications such as coatings, adhesives, or advanced composites.

InChI:InChI=1/C9H9F3N2O/c1-5(15)14-8-3-2-6(4-7(8)13)9(10,11)12/h2-4H,13H2,1H3,(H,14,15)

Upstream product

• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 396-12-3 N-[2-nitro-4-(trifluoromethyl)phenyl]acetamide 

Downstream Products

• 79759-90-3 1-methyl-2-oxo-5-(trifluoromethyl)-2,3-dihydrobenzimidazole 
• 313485-96-0 2-phenylazo-4-(trifluoromethyl)aniline 
• 313485-97-1 6-trifluoromethyl-N-phenyl-1H-benzo[d]imidazol-1-amine 
• 900863-43-6 N-(2-{3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ureido}-4-trifluoromethylphenyl)acetamide 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

Syntheses and properties of 1-methyl-3-phenylaminobenzimidazolium salts, models of DNA adducts of N7-arylaminodeoxyguanosinium salt

When arylaminating carcinogens are administered to cells, they mainly generate the C8-arylamino-2'-deoxyguanosine adduct in DNA. A mechanism for this was proposed in which N7-arylaminated 2'-deoxyguanosine acts as an intermediate; however, it remained unclear whether this is actually the case. To elucidate the mechanisms involved in the generation of this adduct, a series of 5-substituted 1-methylbenzimidazole derivatives were used as models of the imidazole moiety of 2'-deoxyguanosine. Syntheses of a series of 5-substituted (CH3, H, F, CF3, or NO2) 1-methyl-3-phenylaminobenzimidazolium salts (7) and their related compounds were carried out, and the chemical characteristics of these products were examined. Heating compound 7 at 80 °C for 48 h in H2O/MeOH provided 5-substituted 1-methyl-2-oxo-2,3-dihydrobenzimidazoles but only when this compound contained a CF3 or NO2 substituent. Compound 7 decomposed in alkaline media, and its rate of decomposition increased when this compound had a stronger electron-withdrawing substituent. The product obtained under these conditions was 4-substituted N1-methyl-2-phenylazoaniline. On the other hand, when 1-methyl-3-(4-nitrophenylamino)benzimidazolium salt was treated under the same conditions as described above, it generated a demethylated product, 1-(4-nitrophenylamino)benzimidazole, when heated in H2O/MeOH and N1-formyl-N1-methyl-2-phenylazoaniline when treated in alkaline media. When the chemical characteristics of 3-phenylamino and 3-amino groups were compared using 3-substituted 1-methyl-5-(trifluoromethyl)benzimidazoles, the 3-phenylamino derivative was found to be more reactive.