97055-33-9

Usage

Chemical Properties

White Solid

Uses

Intermediate in the preparation of furan based mutagens.

Upstream product

• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 1779-58-4 (methyloxycarbonylmethyl)triphenylphosphonium bromide 
• 632-21-3 1,1,3,3-tetrachloropropanone 
• 1768-31-6 pentachloroacetone 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 77439-76-0 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone 
• 97055-35-1 2,3,4,4-Tetrachloro-3-dichloromethyl-butyric acid methyl ester 
• 97055-37-3 2,4,4-trichloro-3-(dichloromethyl)-crotonic acid 
• 97055-36-2 methyl 2,4,4-trichloro-2(dichloromethyl)crotonate 
• 97055-38-4 3-chloro-4-(dichloromethyl)-5-methoxy-2,5-dihydrofuran-2-one 

Relevant academic research and scientific papers

Synthesis of chlorinated 5-hydroxy 4-methyl-2(5H)-furanones and mucochloric acid

An improved procedure for the synthesis of chlorinated 5-hydroxy-4-methyl-2(5H)-furanones is described. By this method also carbon-labelled (13C and 14C at C-3) hydroxyfuranones, including mucochloric acid, can be prepared. Each step of the method was examined in an effort to optimize both the yield and the purity of the compounds.

Synthesis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a potent mutagen

Starting from tetrachloroacetone 1 and (carbomethoxymethylene)triphenylphosphorane 4, the title compound 16 was prepared in five steps in 44percent yield.Spectroscopic and chromatographic data indicated that this material was identical to a potent mutagen isolated from kraft pulp chlorination effluent.Various mutant Salmonella typhimurium strains (TA 98, 100, and 1537) behaved similarly when incubated with either 16 or the isolated mutagen.