97055-38-4Relevant academic research and scientific papers
Derivatization of the mutagen MX (3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone) with butyl alcohols prior to GC-MS analysis
Nawrocki, Jacek,Andrzejewski, Przemyslaw,Jelen, Henryk,Wasowicz, Erwin
, p. 1891 - 1896 (2001)
An extremely potent mutagen, 3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is commonly present in chlorinated drinking water. Due to its high mutagenic activity and according to WHO guidelines its concentration should be controlled in drinking waters. Determination of MX is difficult due to the low (ppt) levels at which the compound usually exists in drinking waters. Results obtained with butanols as MX derivatization agents are shown and derivatization with sec-butanol is presented as a method which significantly lowers GC/MS detection levels of MX. Copyright
Synthesis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a potent mutagen
Padmapriya, Abeysinghe A.,Just, George,Lewis, Norman G.
, p. 828 - 832 (2007/10/02)
Starting from tetrachloroacetone 1 and (carbomethoxymethylene)triphenylphosphorane 4, the title compound 16 was prepared in five steps in 44percent yield.Spectroscopic and chromatographic data indicated that this material was identical to a potent mutagen isolated from kraft pulp chlorination effluent.Various mutant Salmonella typhimurium strains (TA 98, 100, and 1537) behaved similarly when incubated with either 16 or the isolated mutagen.
