97091-02-6

Upstream product

• 15646-46-5 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 408315-08-2 N-(6-oxo-1,6-dihydro-pyrimidin-5-yl)-benzamide 
• 855420-01-8 5-methylsulfanyl-2-phenyl-oxazolo[5,4-d]pyrimidine 
• 120208-41-5 2-phenyl-oxazolo[5,4-d]pyrimidine 
• 97091-03-7 5-benzoylamino-2-(p-aminosulfonyl)anilino-4-hydroxy-pyrimidine 

Relevant academic research and scientific papers

The use of 4-cyanoaminomethylene-2-phenyl-5(4H)-oxazolone in the synthesis of some heteroarylaminomethylene substituted 5(4H)-oxazolones

The use of 4-cyanoaminomethylene-2-phenyl-5(4H)-oxazolone in the synthesis of some 4-heteroarylaminomethylene-2-phenyl-5(4H)-oxazolones was studied. Synthesis of 4-(1,2,4-oxadiazol-3-yl)aminomethylene-2-phenyl-5(4H)-oxazolone is described.

Synthesis and antibacterial activity of pyrimidinylureidopenicillins

The 6R-[(R)-2-[3-[5-pyrimidinyl]ureido]-2-(4-hydroxyphenyl)acetamido]-penicill anic acids, prepared by two synthetic routes, exhibit broad antimicrobial activity against Gram-positive and Gram-negative bacteria. Their structure-activity relationships are discussed. 6R-[(R)-2-[3-[2-(p-aminosulfonyl)anilino-4-hydroxy-5-pyrimidinyl]ureido]-2 -(4-hydroxyphenyl)acetamido]-penicillanic acid, sodium salt (VX-VC 43), the most active compound, shows very low MIC (minimal inhibitory concentration) values against clinically important Gram-negative bacteria, primarily Pseudomonas aeruginosa.