97132-93-9Relevant articles and documents
Synthesis and Biological Evaluation of Indole-2-carbohydrazide Derivatives as Anticancer Agents with Anti-angiogenic and Antiproliferative Activities
Zhang, Jianqiang,Liu, Tongyang,Chen, Mei,Liu, Feifei,Liu, Xingyuan,Zhang, Jihong,Lin, Jun,Jin, Yi
, p. 1181 - 1192 (2018/06/26)
A novel series of indole-2-carbohydrazide derivatives were synthesized, characterized, and evaluated for their antiproliferative activities against two cancer cell lines, HCT116 and SW480, and a normal human fetal lung fibroblast cell line, MRC-5. Among this series, compound 24 f displayed potent cytotoxic activities in vitro against HCT116 and SW480 cell lines with GI50 values of 8.1 and 7.9 μm, respectively, and was inactive against MRC-5 cells. The newly synthesized compounds were also evaluated for anti-angiogenesis capabilities by chick chorioallantoic membrane, human umbilical vein endothelial cell (HUVEC) migration, and endothelial microtubule formation assays. Moreover, the effects of 24 f on the vascular endothelial growth factor receptor-2 and the signaling pathway in HUVECs indicated that this compound inhibits VEGFR-2 and its downstream related proteins. These results indicate that compound 24 f, as well as the other derivatives, are promising inhibitors of angiogenesis.
Indoles, II: Synthesis of 1,3,4-oxadiazolylindoles and indolyl(pyrazolyl)methanones
Ghoneim,Lehmann,Abd El-Fattah,et al.
, p. 318 - 327 (2007/10/02)
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