97132-93-9Relevant academic research and scientific papers
Synthesis and Biological Evaluation of Indole-2-carbohydrazide Derivatives as Anticancer Agents with Anti-angiogenic and Antiproliferative Activities
Zhang, Jianqiang,Liu, Tongyang,Chen, Mei,Liu, Feifei,Liu, Xingyuan,Zhang, Jihong,Lin, Jun,Jin, Yi
, p. 1181 - 1192 (2018/06/26)
A novel series of indole-2-carbohydrazide derivatives were synthesized, characterized, and evaluated for their antiproliferative activities against two cancer cell lines, HCT116 and SW480, and a normal human fetal lung fibroblast cell line, MRC-5. Among this series, compound 24 f displayed potent cytotoxic activities in vitro against HCT116 and SW480 cell lines with GI50 values of 8.1 and 7.9 μm, respectively, and was inactive against MRC-5 cells. The newly synthesized compounds were also evaluated for anti-angiogenesis capabilities by chick chorioallantoic membrane, human umbilical vein endothelial cell (HUVEC) migration, and endothelial microtubule formation assays. Moreover, the effects of 24 f on the vascular endothelial growth factor receptor-2 and the signaling pathway in HUVECs indicated that this compound inhibits VEGFR-2 and its downstream related proteins. These results indicate that compound 24 f, as well as the other derivatives, are promising inhibitors of angiogenesis.
Synthesis of Substituted 2-(1',3',4'-Oxadiazol-2'-yl)indoles
Sinnur, K. H.,Siddappa, S.,Hiremath, Shivayogi P.,Purohit, Muralidhar G.
, p. 716 - 720 (2007/10/02)
Substituted indole-2-carboxylic acid hydrazides (2) on refluxing with ethyl orthoformate give the respective 2-(1',3',4'-oxadiazol-2'-yl)indoles (4).These compounds have also been obtained by reacting 2 with formamide to get the corresponding N-formyl der
