97149-60-5

Upstream product

• 123703-07-1 1-ethoxycarbonyl-3-(5'-phenyl-1',2',4'-thiadiazol-3'-yl)thiourea 
• 97149-59-2 3--5-phenyl-1,2,4-thiadiazole 
• 27182-54-3 5-phenyl-1,2,4-thiadiazol-3-amine 

Downstream Products

• 97149-62-7 N-[5-Phenyl-3'-(5-phenyl-[1,2,4]thiadiazol-3-ylamino)-[3,4']bi[[1,2,4]thiadiazolyl]-(5'E)-ylidene]-acetamide 
• 89880-03-5 N-(5-phenyl-1,2,4-thiadiazol-3-yl)urea 
• 97149-61-6 5-imino-4-(5'-phenyl-1',2',4'-thiadiazol-3'-yl)-3-(5'-phenyl-1',2',4'-thiadiazol-3'-ylamino)-4,5-dihydro-1,2,4-thiadiazole 

Relevant academic research and scientific papers

Addition-Cyclisations of Ethoxycarbonyl Isothiocyanate with Hydrazine Derivatives as a Source of Thiadiazoles and Triazoles

Ethoxycarbonyl isothiocyanate reacts additively with hydrazine, ethoxycarbonylhydrazine, as well as amino- and 1,2-diaminoguanidine.Simultaneous or subsequent cyclisation of the resulting 1:1- or 2:1-adducts in acidic or alkaline media yields substituted 1,3,4-thiadiazoles or 1,2,4-triazoles, respectively.

1,2,4-Thiadiazolylureas. A Postcript to the Oxidative Cyclisation of Thionoamidines

The identity of authentic 5-phenyl-3-ureido-1,2,4-thiadiazole synthesized from the pre-formed heterocycle, and of the product of the oxidative cyclisation of N1-carbamoyl-N3-thiobenzoylguanidine, confirms the structure of 5-substituted-3-ureido-1,2,4-thiadiazoles obtained by either route.