97151-10-5Relevant academic research and scientific papers
Stereoselective synthesis of triarylethylenes via copper-palladium catalyzed decarboxylative cross-coupling: Synthesis of (Z)-tamoxifen
Cahiez, Gérard,Moyeux, Alban,Poizat, Ma?l
supporting information, p. 8982 - 8984 (2014/08/05)
The first Cu/Pd-catalyzed decarboxylative cross-coupling of 3,3-diarylacrylic acids with aryl bromides is described. Triarylethylenes were obtained in high yields with excellent stereoselectivities. This methodology was successfully applied to the stereos
Trans-stilbene as a starting material for the synthesis of tamoxifen based on palladium-catalyzed cross-coupling reactions
Nunes, Carolina M.,Limberger, Jones,Poersch, Silvia,Seferin, Marcus,Monteiro, Adriano L.
experimental part, p. 2761 - 2765 (2010/01/21)
(Z)-Tamoxifen was synthesized from a simple olefin (trans-stilbene) in 5 steps and 40% overall yield (Z/E = 74:26). The phenyl substituted group (4-Me2NCH2CH2OC6H4) was attached by a bromination-dehydrobromination-Suzuki reaction sequence. Subsequently, the ethyl group was attached to the triarylated olefin by a bromination-Negishi reaction sequence. Both the Suzuki and Negishi cross-coupling processes are stereospecific, and the stereo-selectivity depends only on the bromination-dehydrobromination reactions. (Z)-Tamoxifen was also obtained from trans-stilbene in only 3 steps by using Heck reaction-bromination- Negishi reaction sequence in 57% overall yield (Z/E = 65:35). Georg Thieme Verlag Stuttgart.
Palladium-Catalyzed cross-coupling og Vinylalanes with aryl halides
Al-Hassan, Mohammed I.
, p. 1413 - 1420 (2007/10/02)
Synthesis of tri-and tetrasubstituted olefins was achieved via palladium-catalyzed cross-coupling of vinylalanes with arylhalides.
