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Usage

Uses

Used in Pharmaceutical Industry:
MONO-6-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN is used as a pharmaceutical excipient for enhancing the solubility and bioavailability of poorly water-soluble drugs. The permanent positive charges on the γ-cyclodextrin derivatives can improve the interaction with negatively charged biological membranes, facilitating drug absorption and delivery.
Used in Cosmetic Industry:
MONO-6-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN is used as a stabilizing agent in cosmetic formulations. The γ-cyclodextrin derivatives can form inclusion complexes with various fragrances, dyes, and active ingredients, enhancing their stability, solubility, and controlled release.
Used in Food Industry:
MONO-6-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN is used as a food additive to improve the taste, texture, and shelf life of food products. The γ-cyclodextrin derivatives can encapsulate and protect sensitive food ingredients, such as flavors and antioxidants, from degradation and oxidation.
Used in Environmental Industry:
MONO-6-O-(P-TOLUENESULFONYL)-GAMMA-CYCLODEXTRIN is used as an environmental remediation agent for the removal of pollutants from water and soil. The γ-cyclodextrin derivatives can form complexes with various contaminants, such as heavy metals and organic pollutants, enabling their efficient extraction and separation from the environment.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 17465-86-0 cyclomaltooctaose 

Relevant academic research and scientific papers

Enhanced delivery of daidzein into fibroblasts and neuronal cells with cationic derivatives of gamma-cyclodextrin for the control of cellular glycosaminoglycans

Two cationic derivatives of γ-cyclodextrin (GCD) were synthesized by functionalization with glycidyltrimethylammonium chloride (GTMAC) and ethylenediamine (EDA). Both these derivatives (GCD-GTMAC and GCD-EDA) have been shown to interact strongly with anio

Enzymatic Preparation of Specifically Modified Linear Maltooligosaccharides through Taka-amylase A-catalyzed Hydrolysis of 6-O-Arenesulfonyl-γ-cyclodextrins

6-O-Arenesulfonyl-γ-cyclodextrins were hydrolyzed enzymatically by Taka-amylase A to give 6''-O-arenesulfonylated maltotetraoses and 6''-O-arenesulfonylated maltotrioses.

PH-Controlled Chirality Inversion in Enantiodifferentiating Photocyclodimerization of 2-Antharacenecarboxylic Acid Mediated by γ-Cyclodextrin Derivatives

Several γ-cyclodextrin (γ-CDx) derivatives were used as chiral hosts for the photocyclodimerization of 2-anthracenecarboxylic acid (AC). The effect of pH on photoreactivity and stereochemical outcome of photoproducts was investigated. Upon changing the so

Clockwise-counterclockwise differentiation on the upper rim of a monofunctional γ-cyclodextrin: Efficient topological control in the syntheses of capped cyclodextrins

Intramolecular condensation of 6A-(N-dansyl-l-cysteine)-γ- cyclodextrin occurred only at 6B-OH of the many OH groups to afford the corresponding lactone with an exo-topology. The Royal Society of Chemistry.

Photocatalytic Supramolecular Enantiodifferentiating Dimerization of 2-Anthracenecarboxylic Acid through Triplet-Triplet Annihilation

Visible-light-driven enantiodifferentiating photodimerization of 2-anthracenecarboxylic acid (AC) sensitized by Schiff base Pt(II) complex-grafted γ-cyclodextrins leads the first triplet-triplet annihilation-based catalytic photochirogenesis. The syn-head

Supramolecular Assembly-Improved Triplet–Triplet Annihilation Upconversion in Aqueous Solution

Water-soluble 9,10-diphenylanthracene-modified γ-cyclodextrin derivatives A1 and A2, in which the γ-cyclodextrin unit serves as a molecular host for a binding sensitizer, and the 9,10-diphenylanthracene moiety plays a role as an emitter/annihilator, were synthesized to investigate the supramolecular triplet–triplet annihilation (TTA) upconversion in aqueous solution. Both A1 and A2 readily aggregate and form nanoscale assemblies in water as a combined result of host–guest complexation and π–π stacking among the 9,10-diphenylanthracenes. The aggregation behavior of the supramolecular emitters was fully characterized by using a diversity of methods, including dynamic light scattering (DLS), SEM, NMR, fluorescence, and circular dichroism studies. Fluorescence spectroscopic analysis reveals that the emitters have high fluorescence quantum yields in water (82 and 90 % for A1 and A2, respectively), thus demonstrating that aggregation does not quench the fluorescence. By using a coordinated ruthenium sensitizer, a high TTA upconversion quantum yield of up to 6.9 % was observed for this supramolecular TTA system, which is significantly higher than the value (0.5 %) obtained with nonassembled emitters in organic solvent and in contrast to the fact that TTA upconversion emission in aqueous solution is usually low or negligible. We ascribe the strong TTA upconversion emission in the present supramolecular assembly system to an efficient TTA process, which is facilitated along the stacked emitters by triplet energy migration and improved triplet–triplet energy transfer through host–guest complexation.

Mechanochemical Preparation of Stable Sub-100 nm γ-Cyclodextrin:Buckminsterfullerene (C60) Nanoparticles by Electrostatic or Steric Stabilization

Buckminster fullerene (C60)′s main hurdle to enter the field of biomedicine is its low bioavailability, which results from its extremely low water solubility. A well-known approach to increase the water solubility of C60 is by comple

A complete series of 6-deoxy-monosubstituted tetraalkylammonium derivatives of α-, β-, and γ-cyclodextrin with 1, 2, and 3 permanent positive charges

An efficient synthetic route toward the preparation of a complete series of monosubstituted tetraalkylammonium cyclodextrin (CD) derivatives is presented. Monotosylation of native CDs (α-, β-, γ-) at position 6 gave the starting material. Reaction of monotosylate (mono-Ts-CD) with 45% aqueous trimethylamine gave CDs substituted with one cationic functional group in a single step. Derivatives equipped with a substituent containing two cationic sites separated by an ethylene or a propylene linker were prepared by reacting mono-Ts-CD with neat N,N,N'-trimethylethane-1,2-diamine or N,N,N'- trimethylpropane-1,3-diamine and subsequent methylation by CH3I in good yields. Finally, analogues bearing a moiety with three tetraalkylammonium sites were synthesized by reacting mono-Ts-CD with bis(3-aminopropyl)amine and subsequent methylation. The majority of the presented reactions are very straightforward with a simple work-up, which avoids the need of chromatographic separation. Thus, these reactions are suitable for the multigram-scale production of monosubstituted cationic CDs. 2014 Popr et al;.

Synthesis of C6A-to-C6A and C3A-to-C3A diamide linked γ-cyclodextrin dimers

The syntheses of three new diamide-linked γ-cyclodextrin dimers joined by substitution at either a glucopyranose C6A or C3A carbon are reported. The syntheses involve the reaction of either C6A or C3A amino-substituted γ-cyclodextrin with bis(4-nitrophenyl)succinate to form succinamide linked γ-cyclodextrin dimers or reaction of C6A azide-substituted γ-cyclodextrin with carbon dioxide to form a urea linked γ-cyclodextrin dimer.