97229-14-6Relevant academic research and scientific papers
Solid-phase synthesis of 2,4,6-triaminopyrimidines
Guillier, Fabrice,Roussel, Patrick,Moser, Heinz,Kane, Peter,Bradley, Mark
, p. 3450 - 3458 (2007/10/03)
Substituted pyrimidines are an important class of kinase inhibitors. We therefore developed a synthetic route suitable for the solid-phase synthesis of 2,4,6-triaminopyrimidines through displacement reactions on deactivated pyrimidines. Functionalising th
THE SYNTHESIS AND AMINOLYSIS OF SOME 4-CHLORO-2-(SUBSTITUTED)THIOPYRIMIDINES
Hurst, Derek, T.,Johnson, Matthew
, p. 611 - 616 (2007/10/02)
Some 2-methylthio,2-methylsulphinyl and 2-methylsulphonyl-4-chloropyrimidines have been prepared.In each case which was studied except one the chloride ion was that which was preferentially displaced by diethylamine.The pseudo first order rate constant of for each reaction was determined the results showing that oxidation of the 2-methylthio group greatly enhances the rate of displacement of the 4-chloro group.
