97234-30-5Relevant academic research and scientific papers
Preparation of Enolates from α-Haloketones with n-BuLi, PhMgBr, or Et2Zn via Halogen-Metal Exchange Reaction
Aoki, Yoshitaka,Oshima, Koichiro,Utimoto, Kiitiro
, p. 463 - 464 (2007/10/03)
Metal-halogen exchange of α-iodoketones was performed upon treatment with n-BuLi, PhMgBr, Et2Zn or Me3Al in ether at 0 deg C to give the corresponding metal enolates which reacted with aldehydes to provide the aldol type products in good yields.
NiCl2(PPh3)2-Zn Promoted Deallyloxycarbonylative Directed Aldol Reaction of Allyl β-Keto Carboxylates with Aldehydes th β-Hydroxy Ketones
Nokami, Junzo,Konishi, Haruhisa,Matsuura, Hiroyuki
, p. 2023 - 2026 (2007/10/02)
Regio- and chemospecific deallyloxycarbonylative aldol reaction of allyl (or -lic) α,α-disubstituted β-keto carboxylate with aldehyde was effectively promoted by Ni(0) (NiCl2(PPh3)2-Zn), in which the allyloxycarbonyl group (-COOCH2CH=CH2) was replaced to 1-hydroxyalkyl group (-CH(OH)R, R=alkyl, vinyl, aryl) under mild reaction conditions.
