97274-92-5Relevant academic research and scientific papers
Synthesis method of beclomethasone dipropionate intermediate 11 - β hydroxypregnane
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Paragraph 0011; 0033; 0047-0065, (2020/10/30)
The invention belongs to the field of a medicine preparation, and particularly relates to a synthesis method of an alclometasone dipropionate intermediate of 11-beta hydroxypregna. The 11-beta hydroxypregna is obtained by using a compound shown as a formula II as raw materials and performing free radical reaction under the effects of zinc powder, hexahydrate chromium trichloride and thioglycolic acid. The method provided by the invention has the advantages that the operation is simple; the yield is high; the method is suitable for industrial production.
