97288-78-3

Basic information

• Product Name: 5(2H)-Isoxazolone, 2-benzoyl-3-methyl-
• CAS NO: 97288-78-3
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.197
• Mol File: 97288-78-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5(2H)-Isoxazolone, 2-benzoyl-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(2H)-Isoxazolone, 2-benzoyl-3-methyl-(97288-78-3)
• EPA Substance Registry System: 5(2H)-Isoxazolone, 2-benzoyl-3-methyl-(97288-78-3)

Safety Data

• Hazardous Substances Data: 97288-78-3(Hazardous Substances Data)

Upstream product

• 29871-83-8 3-methyl-2H-isoxazol-5-one 
• 98-88-4 benzoyl chloride 
• 1517-96-0 3-methyl-5-isoxazolone 

Downstream Products

• 877-39-4 4-methyl-2-phenyloxazole 

Relevant articles and documents

Chemistry of 5-oxodihydroisoxazoles. Part 17. Acylation of 5-oxodihydroisoxazoles

2-Unsubstituted isoxazol-5(4H)-ones and -5(2H)-ones may be acylated by acid chlorides, anhydrides or carboxylic acids in the presence of carbodiimides, to give O- and N-acylated products. The solvent, the presence of base and the temperature are found to alter the product ratios dramatically, but the substituents present at C-3 have the greatest effect. Aliphatic acid anhydrides and chlorides generally react at nitrogen, but aroyl halides give significant proportions of O-acylated products. Limited success in converting O-aroyl to N-aroyl isoxazolones is reported.

An Efficient Synthesis of 4-Acyl-5-hydroxy-3-methylisoxazoles through an Acyl-Transfer Reaction

Acylation of 3-methyl-3-isoxazolin-5-one (2a) with acyl chlorides was investigated. 2-Acyl-3-methyl-3-isoxazolin-5-ones 5 and 5-acyloxy-3-methylisoxazoles 6, which were prepared from 2a and acyl halides, underwent acyl-transfer reaction in the presence of