973-67-1

Basic information

• Product Name: 5,6,7-TRIMETHOXYFLAVONE
• Synonyms: 5,6,7-TRIMETHOXYFLAVONE;BAICALEIN TRIMETHYL ETHER;BAICALEIN-5,6,7-TRIMETHYL ETHER;5,6,7-Trimethoxyflavone,97%;2-Phenyl-5,6,7-trimethoxy-4H-1-benzopyran-4-one;5,6,7-Trimethoxy-2-phenyl-4H-1-benzopyran-4-one;5,6,7-trimethoxy-2-phenyl-chromen-4-one;5,6,7-trimethoxy-2-phenylchromen-4-one
• CAS NO: 973-67-1
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.32
• Product Categories: Tri-substituted Flavones
• Mol File: 973-67-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 165-167°C
• Boiling Point: 497.4°C at 760 mmHg
• Flash Point: 221.3°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 4.97E-10mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 5,6,7-TRIMETHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7-TRIMETHOXYFLAVONE(973-67-1)
• EPA Substance Registry System: 5,6,7-TRIMETHOXYFLAVONE(973-67-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 973-67-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A trimethoxyflavone that is the 5,6,7-trimethyl ether derivative of baicalein. It has been isolated from the plant Callicarpa japonica and has been shown to exhibit antiviral activity.

InChI:InChI=1/C18H16O5/c1-20-15-10-14-16(18(22-3)17(15)21-2)12(19)9-13(23-14)11-7-5-4-6-8-11/h4-10H,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 119892-40-9 6-hydroxy-5,7-dimethoxyflavone 
• 6959-90-6 1-(6-hydroxy-2,3,4-trimethoxy-phenyl)-3-phenyl-propane-1,3-dione 
• 70185-52-3 6′-hydroxy-2′,3′,4′-trimethoxychalcone 
• 480-11-5 oroxylin A 
• 7446-08-4 selenium(IV) oxide 
• 123-51-3 i-Amyl alcohol 
• 70185-52-3 (2E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-phenylprop-2-en-1-one 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 100-52-7 benzaldehyde 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 
• 29550-13-8 5,6-dihydroxy-7-methoxyflavone 
• 67047-05-6 4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate 
• 94306-12-4 5-acetoxy-6,7-dimethoxyflavone 
• 142646-44-4 3,5,6,7-tetrahydroxy-2-phenyl-4H-chromen-4-one 
• 480-11-5 oroxylin A 
• 103393-09-5 3-hydroxy-5,6,7-trimethoxy-2-phenyl-4H-benzopyran-4-one 
• 740-33-0 mosloflavone 
• 95937-56-7 5,6,7-Trimethoxy-3-methylflavone 

Relevant articles and documents

Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway

Six rocaglaol derivatives were isolated from Dysoxylum gotadhora, and those compounds showed good cytotoxic activity with IC50 values ranging from 10 to 350 ng/mL against five different cancer cells. Obviously, further total synthesis of rocaglaol derivatives for medical chemistry study is of great significance. Then, twenty six rocaglaol derivatives including 25 new compounds were designed, synthesized, and evaluated for their cytotoxic activities against three human cancer cell lines: human colon cancer cells (HCT116), colorectal cancer stem cells (P6C), and human red leukocyte leukemia cells (HEL), using MTT assay. Most of derivatives showed good cytotoxic activities, with the lowest IC50 being 3.2 nM for HEL cells, which was 169 times stronger than that of the positive control (doxorubicin). Further mechanism study indicated that 11k could significantly suppress MAPK pathway in HCT116 cells, which may responsible for induction of apoptosis and cell cycle arrest.

Baicalein derivative as well as preparation method and application thereof (by machine translation)

The invention discloses a baicalein derivative, structure as shown in the specification : In-flight, R1 A hydrogen, alkyl, is substituted or unsubstituted aryl ;R. 2 The hydrogen, halogen, alkyl, alkoxy, may be substituted or unsubst

Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans

Diversity-oriented synthesis of derivatives of natural products is an important approach for the discovery of novel drugs. In this paper, a series of novel 3,4-diaryl-1H-pyrazoles and 3,5-diaryl-1H-pyrazoles derivatives were synthesized through the one-po