97301-17-2Relevant articles and documents
Synthesis of new C-3 substituted kynurenic acid derivatives
Csámpai, Antal,Fül?p, Ferenc,Lorinczi, Bálint,Szatmári, István
, (2020)
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as morpholine, piperidine, or N-methylpiperazine and aldehydes of markedly different reactivities, like formaldehyde and benzaldehyde. The influence of substituents attached to position 3 on the aminoalkylation was also investigated. Thus, reactions of 3-carbamoyl-substituted precursors with tertiary amine containing side-chains were also tested to afford new KYNA derivatives with two potential cationic centers. By means of NMR spectroscopic measurements, supported by DFT calculations, the dominant tautomer form of KYNA derivatives was also determined.
Hydroamination reactions of alkynes with ortho-substituted anilines in ball mills: Synthesis of benzannulated N-heterocycles by a cascade reaction
Weisse, Maik,Zille, Markus,Jacob, Katharina,Schmidt, Robert,Stolle, Achim
, p. 6511 - 6522 (2015/04/22)
It was demonstrated that ortho-substituted anilines are prone to undergo hydroamination reactions with diethyl acetylenedicarboxylate in a planetary ball mill. A sequential coupling of the intermolecular hydroamination reaction with intramolecular ring cl
