97306-38-2Relevant academic research and scientific papers
Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V
Irie, Kazuhiro,Hagiwara, Nobuyuki,Koshimizu, Koichi,Tokuda, Harukuni,Ito, Yohei,et al.
, p. 1441 - 1446 (2007/10/02)
New 14-O-derivatives of (-)-indolactam V, which has the basic ring-structure of teleocidins without the monoterpenoid moiety, were prepared and their Epstein-Barr virus early antigen (EBV-EA) inducing activity was tested.A series of 14-O-alkyl derivatives was far less active than (-)-indolactam V, but the 14-O-acyl derivatives showed a high EBV-EA inducing activity.These results suggest that the free hydroxyl group at C-14 plays an important role in inducing the EBV-EA, and that the activity of the acyl derivatives arises through hydrolysis of the ester groups.
