97315-21-4

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 177329-71-4 5-Bromo-1-(tert-butyldimethylsilyloxy)-2-methoxybenzene 
• 177472-80-9 (2S)-2-(3,4,5-trimethoxyphenyl)oxirane 
• 97315-20-3 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl bromide 
• 97315-19-0 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol 
• 621-59-0 isovanillin 
• 97315-17-8 5-<(tert-butyldimethylsilyl)oxy>-(+/-)-combretastatin 
• 1439841-37-8 5,5-dimethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborinane 
• 917-57-7 vinyllithium 
• 177329-70-3 (S)-1-(3,4,5-trimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethanol 
• 177329-69-0 (S)-1-(3,4,5-trimethoxyphenyl)-1,2-ethanediol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 13400-02-7 3,4,5-trimethoxy styrene 

Downstream Products

• 82855-09-2 (-)-combretastatin 
• 82855-09-2 (-)-combretastatin 

Relevant academic research and scientific papers

Catalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement

Transition metal catalysis plays a central role in contemporary organic synthesis. Considering the tremendously broad array of transition metal-catalyzed transformations, it is remarkable that the underlying elementary reaction steps are relatively few in

Enantioselective synthesis of natural combretastatin

In a process which appears to be general for the enantioselective synthesis of oxysubstituted 1,2-diarylethanols, a 4-methoxy-3-silyloxyphenyllithium, obtained by bromine-lithium exchange from the corresponding aryl bromide and t-butyllithium, added selectively at the b-carbon of (S)-2,3,4-trimethoxyphenyloxirane, elaborated from the corresponding styrene via Sharpless asymmetric dihydroxylation, to afford an adduct from which natural (-)-combretastatin was obtained by desilylation.