97315-34-9

Upstream product

• 1239461-53-0 methyl 2-(4-(2-(1H-imidazol-1-yl)ethoxy)phenyl)acetate 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 97315-39-4 [4-(2-Chloro-ethoxy)-phenyl]-acetic acid ethyl ester 
• 75912-65-1 [4-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

INHIBITORS OF JUN N-TERMINAL KINASE

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Selective Thromboxane Synthetase Inhibitors. 1. 1--1H-imidazoles

1-(2-Phenoxyethyl)-1H-imidazole was found to be an inhibitor of thromboxane (TxA2) synthetase, but it also inhibited the adrenal cytochrome P-450 enzyme steroid 11β-hydroxylase.The preparation of a series of analogues is described, and activity against TxA2 synthetase, PGI2 synthetase, cyclooxygenase, and steroid 11β-hydroxylase is discussed.Potency against TxA2 synthetase was increased by introduction of a carboxyl group at a suitable distance from the imidazole ring.A distance of 8.1-8.8 Angstroem between N-1 of the imidazole and the carboxyl carbon was found to be optimal.Introduction of a carboxyl group also had the effect of reducing activity against steroid 11β-hydroxylase.The most potent and selective compound was found to be 4-benzoic acid (14).