97352-64-2

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 20110-59-2 [1-13C]-glycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 145142-89-8 C₁₃⁽¹³⁾CH₂₅NO₆ 
• 145142-95-6 C₈⁽¹³⁾CH₁₇NO₄ 

Downstream Products

• 106334-45-6 N-BOC-glycine-1-⁽¹³⁾C benzyl ester 
• 106334-46-7 C₁₅⁽¹³⁾C₂H₂₅NO₅ 
• 106334-47-8 C₁₅⁽¹³⁾C₂H₂₆N₂O₅ 

Relevant academic research and scientific papers

Direct biosynthetic cyclization of a distorted paracyclophane highlighted by double isotopic labelling of l-tyrosine

The biosynthesis of pyrrocidines, fungal PK-NRP compounds featuring a strained [9]paracyclophane, was investigated in Acremonium zeae. We used a synthetic l-tyrosine probe, labelled with oxygen 18 as a reporter of phenol reactivity and carbon 13 as a tracer of incorporation of this exogenous precursor. The (18O)phenolic oxygen was incorporated, suggesting that phenol behaves as a nucleophile during the formation of the bent aryl ether.

Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-

Synthesis and Spectroscopic Properties of 13C- and 15N-Labelled tert-Butoxycarbonylglycines

Three 13C-labelled bromoacetates have been reacted both with 15N-labelled and with unlabelled di-tert-butyl imidodicarbonate and the intermediates selectively deprotected to give the corresponding isotopomeric Boc-glycines for application in peptide synthesis.The products were characterized by 1H, 13C and 15N NMR and FT-IR spectroscopy.Isotope effects on chemical shifts and IR spectra for this set of compounds are tabulated.In addition, from three isotopomers 15N-labelled amides were also prepared.

Synthesis of 13C- and 15N-labelled tert-Butoxycarbonyl (Boc) Glycines and Glycine Amides as Precursors and Simple Models of Backbone-labelled Peptides

Boc-derivatives of the six 13C-labelled glycines with or without 15N have been prepared by a direct approach from the corresponding bromoacetates and three of them converted into 15N-labelled amides by an efficient procedure to give isotopomers with 2-4 adjacent 13C and 15N nuclei; their coupling constants have been recorded.

β-LACTAM SYNTHESIS: CYCLIZATION VERSUS 1,2-ACYL MIGRATION-CYCLIZATION. THE MECHANISM OF THE 1,2-ACYL MIGRATION-CYCLIZATION

The cyclization of hydroxamate 1 unexpectedly afforded two isomeric β-lactams 2 and 3.The mechanism for the formation of 3 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.