97363-16-1

Upstream product

• 97381-27-6 3-Benzylamino-5-benzyloxy-2-((R)-1-hydroxy-ethyl)-pentanethioic acid S-phenyl ester 
• 104862-54-6 (Z)-5-Benzyloxy-pent-2-enoic acid 
• 128217-53-8 (E,Z)-methyl 5-(benzyloxy)-2-pentenoate 
• 104862-52-4 Benzyl-[(1S,2R,3S)-1-(2-benzyloxy-ethyl)-3-hydroxy-2-(2-thioxo-thiazolidine-3-carbonyl)-butyl]-carbamic acid tert-butyl ester 
• 104893-91-6 Benzyl-[1-(2-benzyloxy-ethyl)-3-oxo-3-(2-thioxo-thiazolidin-3-yl)-propyl]-carbamic acid tert-butyl ester 
• 19790-60-4 3-Benzyloxypropanal 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 104862-53-5 (2S,3R)-3-(Benzyl-tert-butoxycarbonyl-amino)-5-benzyloxy-2-((R)-1-hydroxy-ethyl)-pentanoic acid 
• 97363-15-0 Benzyl-[3-benzyloxy-prop-(E)-ylidene]-amine 

Downstream Products

• 97363-17-2 trans-1-benzyl-4-(2'-benzyloxyethyl)-3-(1'R-hydroxyethyl)azetidin-2-one 
• 97363-18-3 (3S,4R)-1-Benzyl-4-(2-benzyloxy-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-azetidin-2-one 
• 97363-17-2 1-Benzyl-4-(2-benzyloxy-ethyl)-3-((R)-1-hydroxy-ethyl)-azetidin-2-one 

Relevant academic research and scientific papers

HIGHLY STEREOSELECTIVE ALDOL-TYPE REACTION OF CHIRAL TIN (II) ENOLATE. FORMAL TOTAL SYNTHESIS OF (+/-)-THIENAMYCIN

Highly efficient internal chiral induction is achieved in the aldol-type reaction of thin (II) enolate generated from 3-amino-substituted butanoylthiazolidine-2-thione.This reaction is successfully applied to the formal total synthesis of (+/-)-thienamyci

Stereocontrolled synthesis of (+)-thienamycin from 3(R)-hydroxybutyric acid

The vinyloxyborane(5), prepared from (+)-S-phenyl-3(R)-butanethioate, 9-BBN triflate and diisopropylethylamine, reacted with N-(3-benzyloxypropylidene)benzylamine to give the β-benzylamino thiol ester(6) in a moderate yield, which was efficiently converted to the optically pure thienamycin intermediate(10).