97388-62-0

Upstream product

• 111-30-8 Glutaraldehyde 
• 119373-39-6 1-benzylcyclopropan-1-ol 
• 98217-26-6 1-phenyl-2,6-dicyanopiperidine 
• 100-39-0 benzyl bromide 
• 98217-33-5 2,6-dibenzyl-2,6-dicyano-1-phenylpiperidine 
• 97388-61-9 2,6-diisocyano-1,7-diphenyl-2,6-ditosylheptane 

Relevant academic research and scientific papers

Ruthenium-catalyzed room-temperature coupling of α-keto sulfoxonium ylides and cyclopropanols for δ-diketone synthesis

Previous transition metal-catalyzed synthesis processes of δ-diketones are plagued by the high cost of the rhodium catalyst and harsh reaction conditions. Herein a low-cost, room temperature ruthenium catalytic method is developed based on the coupling of α-keto sulfoxonium ylides with cyclopropanols. The mild protocol features a broad substrate scope (47 examples) and a high product yield (up to 99%). Mechanistic studies argue against a radical pathway and support a cyclopropanol ring opening, sulfoxonium ylide-derived carbenoid formation, migratory insertion C-C bond formation pathway.

ON THE SYNTHESIS OF 1,n-DIKETONES USING MONO-SUBSTITUTED DERIVATIVES OF TOSYLMETHYL ISOCYANIDE

A new method is described for the synthesis of symmetrical and unsymmetrical diketones.Particularly good results are obtained in the synthesis of 1,6- and 1,5-diketones.Procedures are reported for 1,2-diketones.The moderate results obtained for 1,4-diketones and the lack of success for 1,3-diketones are discussed.