97453-25-3

Basic information

• Product Name: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)
• Synonyms: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5);Dehydroepiandrosterone-d5;Sodium Prasterone Sulfate-d4;Dehydroepiandrosterone-d5 (2,2,3,4,4-d5);Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5) solution;DHEAS-D5 (2,2,3,4,4-D5);Dehydroepiandrosterone-D5-3-sulfate (DHEAS-D5) (2,2,3,4,4,-D5) sodium salt solution;Dehydroepiandrosterone-d5-3-sulfate sodium salt (2,2,3,4,4,-d5)
• CAS NO: 97453-25-3
• Molecular Formula: C19H27NaO5S
• Molecular Weight: 390.46945
• EINECS: 200-659-6
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Isotope Labelled Compounds, Steroids
• Mol File: 97453-25-3.mol
• Article Data: 1

Chemical Properties

• Flash Point: 9 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)(CAS DataBase Reference)
• NIST Chemistry Reference: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)(97453-25-3)
• EPA Substance Registry System: Dehydroepiandrosterone-D5 (DHEA-D5) (2,2,3,4,4-D5)(97453-25-3)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Hazardous Substances Data: 97453-25-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 97453-25-3 differently. You can refer to the following data:
1. Dehydroepiandrosterone-d5 is the labeled analogue of Dehydro Epiandrosterone (D229585). Dehydro Epiandrosterone is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome.
2. Dehydroepiandrosterone-d5 can be used as an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.

Upstream product

• 14456-13-4 (8R,9S,10R,13S,14S)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolan]-3(2H)-one 
• 97453-26-4 C₂₁H₂₆⁽²⁾H₄O₃ 

Relevant articles and documents

Synthesis of Deuterium-Labelled 16α-Hydroxy-4-androstene-3,17-dione and 16α-hydroxydehydroepiandrosterone

16α-Hydroxy-4-androstene-3,17-dione-d5 (4) and 3β,16α-hydroxy-5-androsten-17-one-d6 (10) were synthesized.Treatment of 16α-bromo-5-androstene-3,17-dione (2) with deuterium oxide and methanol-OD gave the 4-en-3-oxo derivative-d 3.The bromide 3 was converted into the 16α-hydroxy-d5 4 via controlled alkaline hydrolysis using sodium hydroxide-OD in deuterium oxide-pyridine. 3β-Hydroxy-5-androstene-17-one-d5 (8), which was obtained from 17,17-ethylenedioxy-5-androsten-3-one (5) via treatment with potassium tert-butoxide in tert-butanol-OD, followed by lithium aluminium tri-tert-butoxydeuteride reduction and then acid hydrolysis, was derivatized to the 16α-bromide 9 by treatment with cupric bromide.The bromide 9 was similarly hydrolyzed to yield the 16α-hydroxide-d6 10.Keywords - controlled alkaline hydrolysis; deuterium labelling; 16α-bromodehydroepiandrosterone-d5; 16α-bromoandrostenedione-d4; 16α-hydroxydehydroepiandrosterone-d6; 16α-hydroxyandrostenedione-d5.