97455-61-3

Basic information

• Product Name: 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI)
• Synonyms: 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI);6-ethoxynicotinaldehyde(SALTDATA: FREE);6-ethoxynicotinaldehyde;6-Ethoxynicotincarboxaldehyde;2-Ethoxypyridine-5-carbaldehyde;6-ethoxy-3-pyridinecarboxaldehyde
• CAS NO: 97455-61-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Product Categories: ALDEHYDE
• Mol File: 97455-61-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 258.8°C at 760 mmHg
• Flash Point: 110.3°C
• Appearance: /
• Density: 1.121g/cm³
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.24±0.22(Predicted)
• CAS DataBase Reference: 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI)(97455-61-3)
• EPA Substance Registry System: 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI)(97455-61-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 97455-61-3(Hazardous Substances Data)

Usage

General Description

3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI) is a chemical compound with the molecular formula C8H9NO2. It is a derivative of pyridinecarboxaldehyde, with an ethoxy group attached at the 6th carbon position. 3-Pyridinecarboxaldehyde, 6-ethoxy- (9CI) is used in various chemical reactions and as a building block in the synthesis of other organic compounds. It has potential applications in the pharmaceutical and agrochemical industries as well. The 6-ethoxy group in this compound may contribute to its specific reactivity and properties, making it useful for a wide range of applications.

InChI:InChI=1/C8H9NO2/c1-2-11-8-4-3-7(6-10)5-9-8/h3-6H,2H2,1H3

Upstream product

• 55849-30-4 5-bromo-2-ethoxypyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 97455-65-7 6-ethoxy-3-pyridinecarboxylic acid 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 85259-10-5 (E)-3-(6-Ethoxy-pyridin-3-yl)-acrylic acid 
• 31594-45-3 2-ethoxy-5-nitropyridine 

Downstream Products

• 265114-31-6 5-(6-ethoxy-3-pyridyl)-1-(4-methylsulfonylphenyl)imidazole 

Relevant articles and documents

Novel indirect AMP-activated protein kinase activators: Identification of a second-generation clinical candidate with improved physicochemical properties and reduced hERG inhibitory activity

This study reports the synthesis and evaluation of novel indirect AMP-activated protein kinase (AMPK) activators. The series of compounds selectively inhibited cell growth in several human breast cancer cell lines by activating AMPK. We performed back-up medicinal chemistry synthetic research on ASP4132, a previously reported as a compound for clinical development that acts as an indirect AMPK activator. This led to the successful identification of 4-({4-[5-({1-[(5-ethoxypyrazin-2-yl)methyl]-4-fluoropiperidin-4-yl}methoxy)-3-methylpyridine-2-carbonyl]piperazin-1-yl}methyl)benzonitrile succinate (27b), a potent, highly aqueous soluble and metabolically stable compound in human hepatocytes. Compound 27b also showed weaker human Ether-a-go-go Related Gene (hERG) inhibitory activity than that of compound 13 and ASP4132. Therefore, 27b was a promising AMPK activator and a second-generation clinical candidate for treatment for human cancer.

6-n-Alkoxy-3-Pyridinecarboxaldehydes: New Intermediates to Liquid Crystals. Properties of Some Derivatives.

The synthesis of new intermediates to liquid crystals, a series of 6-n-alkoxy-3-pyridinecarboxaldehydes is described.The mesomorphic properties of their precursors, the 6-n-alkoxy-3-pyridinecarboxylic acids are reported.Some derivatives of the carboxaldeh