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γ-Carboxyglutamyl-phenylalanine, also known as γ-carboxyglutamate-phenylalanine or Gla-Phe, is a unique peptide compound consisting of two amino acids: γ-carboxyglutamate (Gla) and phenylalanine (Phe). This chemical structure is significant because it is a key component found in certain proteins, particularly those involved in blood clotting, such as prothrombin and other vitamin K-dependent clotting factors. The γ-carboxylation of glutamate residues is a post-translational modification that is essential for the biological activity of these proteins, as it allows them to bind calcium ions, which is crucial for their function in the coagulation cascade. The Gla-Phe sequence is not only important for the structure and function of these proteins but also serves as a marker for the presence of γ-carboxyglutamate, which is a rare and distinctive feature in the proteome.

97458-34-9

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97458-34-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 97458-34-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,4,5 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 97458-34:
(7*9)+(6*7)+(5*4)+(4*5)+(3*8)+(2*3)+(1*4)=179
179 % 10 = 9
So 97458-34-9 is a valid CAS Registry Number.

97458-34-9Downstream Products

97458-34-9Relevant academic research and scientific papers

ENZYMATICALLY CATALYZED SYNTHESIS OF DIPEPTIDES OF γ-CARBOXY-L-GLUTAMIC ACID FROM BENZYLOXYCARBONYL-γ-CARBOXY-DL-GLUTAMIC-ACID

Cerovsky, Vaclav,Jost, Karel

, p. 878 - 884 (2007/10/02)

Enantioselective reaction of benzyloxycarbonyl-γ-carboxy-DL-glutamic acid with phenylhydrazines of various amino acids and with leucine, protected with various carboxy-protecting groups, has been studied.

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