97467-11-3

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 21428-65-9 2,2-dibromo-5,5-dimethylcyclohexane-1,3-dione 
• 1032818-10-2 [2-bromo-1-(4-methylphenyl)ethyl]dimethylsulfonium bromide 
• 126-81-8 dimedone 
• 13107-39-6 2-(4-methylphenyl)oxirane 

Relevant academic research and scientific papers

Acid-Catalyzed Ring-Opening Cyclization of Spirocyclopropanes for the Construction of a 2-Arylbenzofuran Skeleton: Total Synthesis of Cuspidan B

Acid-catalyzed ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes under metal-free conditions proceeded smoothly at room temperature to provide 2-aryl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-ones in excellent yields without the formation

An organocatalyzed highly regioselective one-pot approach to the synthesis of tetrahydrobenzofuranones

An organocatalyzed highly regioselective synthesis of substituted tetrahydrobenzofuran-4-ones based on the ring opening followed by cyclization of epoxides with enamines of 1,3-cyclohexanediones in a domino fashion is described. It is a high yielding (74-93%) synthetic protocol tolerant to a wide range of substrates. Ambient temperature, organocatalytic approach, atom-economy, and formation of water as the only by-product are some of the attractive features of the present methodology.

Regioselective Synthesis of Dihydrofurans from 2,2-Dibromo 1,3-Diones and Olefins Using Copper

2,2-Dibromo 1,3-diones reacted with copper powder and olefin to give 2,3-dihydrofuran derivatives in a highly regioselective fashion.Acetylenes and 1,3-dienes also reacted with 2,2-dibromo 1,3-diones and copper to afford furan derivatives and 2-vinyl-2,3-