97510-06-0Relevant articles and documents
Synthesys of Single Isomers (E or Z) of Unsatured Carboxylic Acids by the Horner-Wittig Reaction
Levin, Daniel,Warren, Stuart
, p. 1799 - 1808 (2007/10/02)
Alkyl(diphenyl)phosphine oxides (5) are used to synthesize pure E or Z isomers of unsatured acids.The keto acids (10), made by two routes, are reduced to hydroxy acids whose crystalline lactones (12) can be separated and purified.Stereospecific elimination of Ph2PO2- gives the unsatured acids.
STEREOCHEMICALLY CONTROLLED SYNTHESIS OF UNSATURATED ACIDS VIA DIPHENYLPHOSPHINOYL(Ph2PO)-KETOACIDS
Levin, Daniel,Warren, Stuart
, p. 505 - 508 (2007/10/02)
Acylation of phosphine oxide anions with derivatives of cyclic anhydrides or oxidative cleavage of cyclic allyl phosphine oxides gives Ph2PO-ketoacids: reduction, separation of diastereoisomers, and completion of the Horner-Wittig reaction gives single isomers (E or Z) of unsaturated acids.
