97510-99-1Relevant academic research and scientific papers
n-Butyllithium-promoted regioselective elimination of vicinal bis-triflate having an adjacent ether oxygen
Kutsumura, Noriki,Shibuya, Kota,Yamaguchi, Hitoshi,Saito, Takao
, p. 4099 - 4102 (2017)
Regioselective elimination of a vicinal bis-triflate having an adjacent ether oxygen functional group has been developed. Considered in the context of our studies of the regioselective elimination of vicinal dibromide, the key to the mechanism involves the electron-withdrawing inductive effect of the neighboring oxygen functional group. Aliphatic vinyl triflate was shown to be effective in Suzuki–Miyaura cross coupling compared with corresponding aliphatic vinyl bromide.
PEG-supported pyridylthioesters for racemization-free amide synthesis: A reagent that allows simultaneous product formation and removal from the polymer
Benaglia, Maurizio,Guizzetti, Stefania,Rigamonti, Clara,Puglisi, Alessandra
, p. 12100 - 12106 (2007/10/03)
Pyridylthioesters anchored to a modified poly(ethylene glycol) of M w 5000 Da have been prepared in high yields. The thioesters were employed as a convenient starting material for the liquid-phase synthesis of various enantiomerically pure amid
A HIGHLY EFFECTIVE ASYMMETRIC SYNTHESIS OF α-HYDROXY ACIDS BY ALKYLATION OF CHIRAL N-(BENZYLOXYACETYL)-TRANS-2,5-BIS(METHOXYMETHOXYMETHYL)PYRROLIDINE
Enomoto, Masayuki,Ito, Yoshio,Katsuki, Tsutomu,Yamaguchi, Masaru
, p. 1343 - 1344 (2007/10/02)
Alkylation of lithiated N-(benzyloxyacetyl)-trans-2,5-bis(methoxymethoxymethyl)-pyrrolidine proceeded with high stereoselectivity (>96percent de) and subsequent transformations of the alkylated products gave synthetically useful α-benzyloxy acids or α-hydroxy acids of high enantiomeric purity.
