97517-66-3Relevant academic research and scientific papers
TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE
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Page/Page column 47, (2011/07/29)
The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or aired fasting glucose.
NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS
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Page/Page column 34-35; 45-46; 56-57; 66-67; 74; 84; 92; 103-104, (2010/11/28)
The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.
HETEROCYCLIC COMPOUNDS
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Page/Page column 46, (2008/06/13)
New compounds of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.
Directed lithiation of N-(tert-butoxycarbonyl)aminoisoxazole: Synthesis of 4-substituted aminoisoxazoles
Konoike, Toshiro,Kanda, Yasuhiko,Araki, Yoshitaka
, p. 3339 - 3342 (2007/10/03)
Directed lithiation of 3-(Boc-amino)isoxazole 4 and 5-(Boc-amino)isoxazole 9 is described. Dilithioisoxazoles reacted with a variety of electrophiles to give the corresponding 4-substituted isoxazoles.
