97528-24-0

Basic information

• Product Name: N-(2,4-DIMETHYLPHENYL)PIVALAMIDE
• Synonyms: 2',4'-dimethylpivalanilide
• CAS NO: 97528-24-0
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol File: 97528-24-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,4-DIMETHYLPHENYL)PIVALAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-DIMETHYLPHENYL)PIVALAMIDE(97528-24-0)
• EPA Substance Registry System: N-(2,4-DIMETHYLPHENYL)PIVALAMIDE(97528-24-0)

Safety Data

• Hazardous Substances Data: 97528-24-0(Hazardous Substances Data)

Usage

General Description

N-(2,4-DIMETHYLPHENYL)PIVALAMIDE is a chemical compound that falls under the category of pivalamide derivatives. It is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical possesses an amide functional group and a pivaloyl group, which makes it a versatile building block for the creation of various organic molecules. Its specific properties and uses may vary depending on the context in which it is employed, but its synthesis and structure are key to its function in organic chemistry.

Upstream product

• 3282-30-2 pivaloyl chloride 
• 95-68-1 2,4-Xylidine 

Downstream Products

• 1323369-04-5 N-(4-(2-tert-butyl-6,8-dimethyl-4H-benzo[d][1,3]oxazin-4-yl)-2-methylphenyl)pivalamide 
• 1245795-58-7 benzyl 3,5-dimethyl-2-(pivalamido)phenylcarbamate 
• 1245795-51-0 ethyl 3,5-dimethyl-2-(pivalamido)phenylcarbamate 
• 1245795-57-6 2,2,2-trichloroethyl 3,5-dimethyl-2-(pivalamido)phenylcarbamate 
• 69622-41-9 2-(tert-butyl)-5-methyl-1H-indole 
• 1253779-02-0 N-(2-methyl-4-((N-(phenylsulfonyl)phenylsulfonamido)methyl)phenyl)pivalamide 

Relevant articles and documents

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature

The unsymmetrical biaryls (Ar1-Ar2) produced by the catalytic cross-couplings of aryl halides (Ar1-halo) with aryl metallics (Ar2-M) in the loading ratio of 1:1 are popular in chemical synthesis. In contrast, there has been less precedence on the same biaryls produced effectively from two normal aryl C-H bonds with equivalent loading. Here, we report that, in a palladium/oxidant/acid catalytic system at room temperature, one arene (Ar1-H, 1 equiv) can highly selectively couple with the other one (Ar2-H, 1 equiv) to afford the target Ar1-Ar2 just by controlling the directing groups and the substituted groups on their phenyl rings. The utility of this one-one cross-coupling is also demonstrated by synthesis of a few bioactive molecules.

Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization

We report the first introduction of 2-bromo-3,3,3-trifluoropropene (BTP) by directed C-H bond functionalization. The developed method gives straightforward access to α-(trifluoromethyl)styrene derivatives without prior prefunctionalization of the substrates. This palladium-catalysed transformation was applied to a broad range of substrates, and the corresponding trifluoromethylated products were obtained in good yields. This approach represents an alternative pathway to the classical method previously used to access such molecules.

Remote amide-directed palladium-catalyzed benzylic C-H amination with N-fluorobenzenesulfonimide

An unprecedented remote amide-directed palladium-catalyzed intermolecular highly selective benzylic C-H amination with N-fluorobenzenesulfonimide is developed, which represents the first direct benzylic C-H amination with a non-nitrene nitrogen source. This methodology provides a novel approach to circumvent the common ortho aromatic C-H selectivity in directed palladium catalyzed C-H functionalization.