97534-21-9 Usage
Uses
Merbarone has been used to study its effect on the occurrence of DNA lesions.
General Description
A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 97534-21-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,5,3 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 97534-21:
(7*9)+(6*7)+(5*5)+(4*3)+(3*4)+(2*2)+(1*1)=159
159 % 10 = 9
So 97534-21-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
97534-21-9Relevant articles and documents
Pharmacophore Hybridization to Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Ortega, Jose Antonio,Riccardi, Laura,Minniti, Elirosa,Borgogno, Marco,Arencibia, Jose M.,Greco, Maria L.,Minarini, Anna,Sissi, Claudia,De Vivo, Marco
, p. 1375 - 1379 (2018)
We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on hu
